ArticleOpen medicine (Warsaw, Poland)2019
The Factors Affecting Early Death in Newly Diagnosed APL Patients.
Article in Open medicine (Warsaw, Poland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Causes and risk factors for early death in adult patients with acute promyelocytic leukemia: a real-life experience.Hematology, transfusion and cell therapy · 2024Article
- Analysis of early death in critically ill patients with acute promyelocytic leukaemia in the HICU.Scientific reports · 2024Article
- Clinical characteristics and analysis of related factors associated with early death in newly diagnosed patients with acute promyelocytic leukemia.Discover oncology · 2024Article
- Acute promyelocytic leukemia with additional chromosome abnormalities in a patient positive for HIV: A case report and literature review.Oncology letters · 2024Article
- Disseminated Intravascular Coagulation in Acute Promyelocytic Leukemia Patients: A Retrospective Analysis of Outcomes and Healthcare Burden in US HospitalsTurkish journal of haematology : official journal of Turkish Society of Haematology · 2024Article
- Analysis of early and treatment related deaths among children and adolescents with acute myeloid leukemia in Poland: 2005-2023.Frontiers in pediatrics · 2024Article
- Effects of peripheral blood leukocyte count and tumor necrosis factor-alpha on early death in acute promyelocytic leukemia.BMC cancer · 2023Article
- Influence of cytokines on early death and coagulopathy in newly diagnosed patients with acute promyelocytic leukemia.Frontiers in immunology · 2023Article
- The evaluation of risk factors leading to early deaths in patients with acute promyelocytic leukemia: a retrospective study.Annals of hematology · 2022Article
- Incidence, characteristics and risk factors of hypofibrinogenemia associated with tigecycline: A multicenter retrospective study in China.Frontiers in pharmacology · 2022Article
- The role of adjuvant chemotherapy in the management of acute promyelocytic leukemia differentiation syndrome.Frontiers in oncology · 2022Article
- Predictors of early death and clinical features in newly diagnosed patients with low-intermediate risk acute promyelocytic leukemia.Frontiers in oncology · 2022Article
- Gene mutations in acute promyelocytic leukemia early death in patients treated with arsenic trioxide alone.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Article
- An End-to-End Pipeline for Early Diagnosis of Acute Promyelocytic Leukemia Based on a Compact CNN Model.Diagnostics (Basel, Switzerland) · 2021Article
- Coagulopathy in Acute Promyelocytic Leukemia: Can We Go Beyond Supportive Care?Frontiers in medicine · 2021Review
- [Analysis of early death factors and prognosis of acute promyelocytic leukemia].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimIn the past, acute promyelocytic leukemia (APL) was considered as one of the most rapidly lethal form of acute myeloid leukemia (AML). The objective of this study was to assess clinical parameters affecting early death (ED) in patients with APL. MATERIALS AND
methodsForty-three patients with APL who were diagnosed at Hacettepe University Hospital between the years of 2005 and 2018 were evaluated.
resultsIn univariate analyses, presentation with hemorrhage, DIC or infection at diagnosis, ECOG performance score, blast percentage on bone marrow, Sanz score, leukocyte, thrombocyte, fibrinogen and LDH levels were found to be statistically significantly different between patients with ER and patients without ED. In multivariate analysis, presentation with hemorrhage, DIC or infection at diagnosis, ECOG performance score, blast percentage on bone marrow, Sanz score, leukocyte, thrombocyte, fibrinogen, and LDH levels were found to be independent factors that are related with higher rate of ED in 30 days after treatment.
conclusionInduction chemotherapy should be started as soon as possible after diagnosis of APL. Improving ED rates may become the greatest challenge for the future treatment of the diseases.
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