Evidence map›Paper›PMID 31565666›Full record

ArticleJournal of probiotics & health2019

Human Breast Milk Promotes the Immunomodulatory Function of Probiotic

Thomas K Hoang, Jasmin Freeborn, Ting Wang, Tu Mai, Baokun He, Sinyoung Park, Dat Q Tran, Stefan Roos, J Marc Rhoads, Yuying Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of probiotics & health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Heat-killedFrontiers in microbiology · 2022
    Article
  3. Chemical characterization ofRSC advances · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Thomas K HoangDepartment of Pediatrics, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas 77030, United States.
Jasmin FreebornDepartment of Pediatrics, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas 77030, United States.
Ting WangDepartment of Pediatrics, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas 77030, United States.
Tu MaiDepartment of Pediatrics, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas 77030, United States.
Baokun HeDepartment of Pediatrics, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas 77030, United States.
Sinyoung ParkDepartment of Pediatrics, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas 77030, United States.
Dat Q TranDepartment of Pediatrics, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas 77030, United States.
Stefan RoosDepartment of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden.
J Marc RhoadsDepartment of Pediatrics, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas 77030, United States.
Yuying LiuDepartment of Pediatrics, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas 77030, United States.
Swedish University of Agricultural Sciences · SE

Funding

Mechanisms of L. reuteri in regulating intestinal inflammationR01AT007083 · NCCIH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, YUYING, RHOADS, JON MARC · 2014 to 2018
$1.7M
NCCIH NIH HHS R01 AT007083
6 · The paper itself

Abstract

BACKGROUND AND

objectiveBreast milk has many growth-promoting and immune-active components, including transforming growth factor-β, lactoferrin, lysozyme, immunoglobulin A, and prebiotics such as the human milk oligosaccharides. Treatment with

methodsNewborn rats were divided into 8 feeding groups, including dam-fed ± LR (10 RESULTS AND

conclusion(1) Formula feeding increased intestinal CD3+ T cells, CD4+ helper T (TH) cells and CD11c+ DCs, pro-inflammatory effects which were reversed by HBM. (2) When comparing HBM-fed with formula-fed newborns, HBM supplementation produced a lower percentage of CD4+ TH cells and a higher percentage of CD8+ (cytotoxic) T cells, while reducing protein levels of IL-1β and CINC-1 in the intestine. (3) Probiotic LR feeding maximally stimulated the percentage of intestinal Tregs and tDCs when the pups were fed HBM. In conclusion, HBM reduced formula-induced intestinal gut immune activation, and the addition of LR further promoted immune tolerance.

Indexed as

Dendritic cellFormulaHuman breast milkIntestineLactobacillus reuteriNeonatal ratsProbioticT cell

Identifiers

PMID31565666
PMCPMC6764460
OpenAlexW2970623664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.