Evidence map›Paper›PMID 31565659›Full record

ReviewJournal of immunology research2019

Role of Inflammatory Cell Subtypes in Heart Failure.

Derek Strassheim, Edward C Dempsey, Evgenia Gerasimovskaya, Kurt Stenmark, Vijaya Karoor

Abstract readReview
In one paragraph

Review in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. CITE-Seq Analysis Reveals a Differential Natural Killer CellInternational journal of molecular sciences · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Derek StrassheimCardiovascular Pulmonary Research Laboratory, University of Colorado Denver, Aurora CO, USA.ORCID https://orcid.org/0000-0001-5264-6792
Edward C DempseyCardiovascular Pulmonary Research Laboratory, University of Colorado Denver, Aurora CO, USA.
Evgenia GerasimovskayaCardiovascular Pulmonary Research Laboratory, University of Colorado Denver, Aurora CO, USA.
Kurt StenmarkCardiovascular Pulmonary Research Laboratory, University of Colorado Denver, Aurora CO, USA.
Vijaya KaroorCardiovascular Pulmonary Research Laboratory, University of Colorado Denver, Aurora CO, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation is a well-known feature of heart failure. Studies have shown that while some inflammation is required for repair during injury and is protective, prolonged inflammation leads to myocardial remodeling and apoptosis of cardiac myocytes. Various types of immune cells are implicated in myocardial inflammation and include neutrophils, macrophages, eosinophils, mast cells, natural killer cells, T cells, and B cells. Recent clinical trials have targeted inflammatory cascades as therapy for heart failure with limited success. A better understanding of the temporal course of the infiltration of the different immune cells and their contribution to the inflammatory process may improve the success for therapy. This brief review outlines the major cell types involved in heart failure, and some of their actions are summarized in the supplementary figure.

Indexed as

Cellular MicroenvironmentAnimalsDisease SusceptibilityHeart FailureHumansImmune SystemLeukocytesMyocardiumMyocytes, Cardiac

Identifiers

PMID31565659
PMCPMC6745095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.