ReviewCureus2019
Primary Spinal Astrocytomas: A Literature Review.
Review in Cureus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04211974 (Genomic Landscape of Intramedullary Astrocytoma), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genomic Landscape of Intramedullary Astrocytoma
Who cites it
26 citing papers in PubMed.
- Extracellular vesicles in spine tumors: biological roles, immune modulation, and therapeutic implications.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Article
- The 4S of spinal astrocytoma: specific location, syrinx, spasticity and score on Modified Mccormick Scale (MMS) predict long term outcomes in patients undergoing surgical resection of intramedullary spinal astrocytomas.Journal of neuro-oncology · 2025Article
- Safety and Efficacy of Stereotactic Radiosurgery in the Management of Primary Spinal Cord Glioblastoma: A Case Report.Cancer management and research · 2025Article
- Holocord intramedullary pilocytic astrocytoma mimicking holocord spinal abscess: a case report and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Advances in imaging modalities for spinal tumors.Neuro-oncology advances · 2024Review
- The Role of Radiotherapy, Chemotherapy, and Targeted Therapies in Adult Intramedullary Spinal Cord Tumors.Cancers · 2024Review
- Epidemiological features of spinal intradural tumors, a single-center clinical study in Beijing, China.BMC musculoskeletal disorders · 2024Article
- Article
- Translational research of boron neutron capture therapy for spinal cord gliomas using rat model.Scientific reports · 2024Article
- Analysis of Spinal Pilocytic Astrocytoma in 12 Case Reports and Literature Review.Journal of the Belgian Society of Radiology · 2024Review
- Radiological characterization of pediatric intramedullary astrocytomas: Do they differ from adults?Brain & spine · 2024Article
- Clinical examination and imaging resources in children and adolescent back pain.Journal of children's orthopaedics · 2023Review
- Complete Versus Incomplete Surgical Resection in Intramedullary Astrocytoma: Systematic Review with Individual Patient Data Meta-Analysis.Global spine journal · 2023Article
- Automated Classification of Intramedullary Spinal Cord Tumors and Inflammatory Demyelinating Lesions Using Deep Learning.Radiology. Artificial intelligence · 2022Article
- Predictors of survival and time to progression following operative management of intramedullary spinal cord astrocytomas.Journal of neuro-oncology · 2022Article
- Differentiating nonradiographic axial spondyloarthritis from its mimics: a narrative review.BMC musculoskeletal disorders · 2022Review
- Article
- Transcriptomic Portraits and Molecular Pathway Activation Features of Adult Spinal Intramedullary Astrocytomas.Frontiers in oncology · 2022Article
- Clinical Manifestations and Diagnosis of Axial Spondyloarthritis.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary spinal astrocytoma is a subtype of glioma, the most common spinal cord tumor found in the intradural intramedullary compartment. Spinal astrocytomas account for 6-8% of all spinal cord tumors and are primarily low grade (World Health Organization grade I (WHO I) or WHO II). They are seen in both the adult and pediatric population with the most common presenting symptoms being back pain, sensory dysfunction, or motor dysfunction. Magnetic Resonance Imaging (MRI) with and without gadolinium is the imaging of choice, which usually reveals a hypointense T1 weighted and hyperintense T2 weighted lesion with a heterogeneous pattern of contrast enhancement. Further imaging which may aid in surgical planning includes computerized tomography, diffusion tensor imaging, and tractography. Median survival in spinal cord astrocytomas ranges widely. The factors most significantly associated with poor prognosis and shorter median survival are older age at initial diagnosis, higher grade lesion based on histology, and extent of resection. The mainstay of treatment for primary spinal cord astrocytomas is surgical resection, with the goal of preservation of neurologic function, guided by intraoperative neuromonitoring. Adjunctive radiation has been shown beneficial and may increase overall survival. The role of adjunctive chemotherapy is employed, however, its benefit has not been clearly defined. Primary spinal cord astrocytomas are rare and challenging to treat. The gold standard treatment is surgical resection. Second-line treatments include radiation and chemotherapy, although, the optimal regimen for adjunctive therapy has not yet been clearly defined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.