Evidence map›Paper›PMID 31565538›Full record

ArticleTremor and other hyperkinetic movements (New York, N.Y.)2019

Changes in Midline Tremor and Gait Following Deep Brain Stimulation for Essential Tremor.

Masa-Aki Higuchi, Ryan T Roemmich, Daniel Martinez-Ramirez, Jaimie A Roper, Lisa A Zukowski, Kelly D Foote, Michael S Okun, Chris J Hass

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Masa-Aki HiguchiDepartment of Neurology, Fixel Institute for Neurological Diseases, Program for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA.
Ryan T RoemmichCenter for Movement Studies, Kennedy Krieger Institute, Baltimore, MD, USA.
Daniel Martinez-RamirezDepartment of Neurology, Fixel Institute for Neurological Diseases, Program for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA.
Jaimie A RoperSchool of Kinesiology, Auburn University, Auburn, AL, USA.
Lisa A ZukowskiDepartment of Physical Therapy, Congdon School of Health Sciences, High Point University, High Point, NC, USA.
Kelly D FooteDepartment of Neurosurgery, University of Florida, Gainesville, FL, USA.
Michael S OkunDepartment of Neurology, Fixel Institute for Neurological Diseases, Program for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA.
Chris J HassProgram for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA.
University of Florida · USAuburn University · USHigh Point University · USKennedy Krieger Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Essential tremor (ET) is a common movement disorder characterized by kinetic and postural tremor in the upper extremities and frequently in the midline. Persons with ET often also exhibit gait ataxia. Previous studies have observed associations between midline tremor severity and gait ataxia in persons with ET, suggesting a common pathophysiology distinct from that of upper extremity tremor. However, a causal link between midline tremor and gait impairment has not been established. Methods: We investigated tremor and gait in 24 persons with ET before and after implantation of unilateral deep brain stimulation into the ventralis intermedius nucleus of the thalamus. Results: Stimulation significantly improved tremor in the targeted upper extremity and midline. However, gait was unaffected at the cohort level. Furthermore, improvement in midline tremor was not significantly associated with gait improvement. Discussion: These findings revealed that midline tremor and gait impairment may be dissociable in persons with ET.

Indexed as

Deep Brain StimulationAgedCohort StudiesEssential TremorFemaleGait Disorders, NeurologicHumansMaleMiddle AgedTreatment OutcomeVentral Thalamic NucleiAtaxiadeep brain stimulationEssential tremorgaitThalamus

Identifiers

PMID31565538
PMCPMC6744814
OpenAlexW2996184730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.