Evidence map›Paper›PMID 31565515›Full record

ArticleBiomedical optics express2019

Photoacoustic imaging of the uterine cervix to assess collagen and water content changes in murine pregnancy.

Yan Yan, Nardhy Gomez-Lopez, Maryam Basij, Amin Vossoughi Shahvari, Felipe Vadillo-Ortega, Edgar Hernandez-Andrade, Sonia S Hassan, Roberto Romero, Mohammad MehrMohammadi

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07784179 (Ultrasound and Photoacoustic Imaging of Hydrocephalus), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07784179 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Ultrasound and Photoacoustic Imaging of Hydrocephalus

TypeinterventionalSponsorMichael McDowellRan2026 to 2029Enrolled250ConditionsHydrocephalus in Infants, Hydrocephalus in ChildrenArmsPAUS imaging
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

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  14. In vivo Raman spectroscopy monitors cervical change during labor.American journal of obstetrics and gynecology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Yan YanDepartment of Biomedical Engineering, Wayne State University, Detroit, MI 48202, USA.
Nardhy Gomez-LopezPerinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland and Detroit, MI 48201, USA.
Maryam BasijDepartment of Biomedical Engineering, Wayne State University, Detroit, MI 48202, USA.
Amin Vossoughi ShahvariDepartment of Chemical Engineering, Wayne State University, Detroit, MI 48202, USA.
Felipe Vadillo-OrtegaPerinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland and Detroit, MI 48201, USA.
Edgar Hernandez-AndradePerinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland and Detroit, MI 48201, USA.
Sonia S HassanPerinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland and Detroit, MI 48201, USA.
Roberto RomeroPerinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland and Detroit, MI 48201, USA.
Mohammad MehrMohammadiDepartment of Biomedical Engineering, Wayne State University, Detroit, MI 48202, USA.ORCID https://orcid.org/0000-0002-9264-9354
National Institutes of Health · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The uterine cervix plays a central role in the maintenance of pregnancy and in the process of parturition. Cervical remodeling involves dramatic changes in extracellular matrix composition and, in particular, of collagen and water content during cervical ripening (a term that describes the anatomical, biochemical, and physiologic changes in preparation for labor). Untimely cervical ripening in early gestation predisposes to preterm labor and delivery, the leading cause of infant death worldwide. Inadequate ripening of the cervix is associated with failure of induction or prolonged labor. The current approach to evaluate the state of the cervix relies on digital examination and sonographic examination. Herein, we present a novel imaging method that combines ultrasound (US) and photoacoustic (PA) techniques to evaluate cervical remodeling by assessing the relative collagen and water content of this organ. The method was tested

Identifiers

PMID31565515
PMCPMC6757472
OpenAlexW2969954258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.