Evidence map›Paper›PMID 31565233›Full record

ArticleCanadian journal of kidney health and disease2019

The Effect of Transplant Volume and Patient Case Mix on Center Variation in Kidney Transplantation Outcomes.

Anne Tsampalieros, Dean Fergusson, Stephanie Dixon, Shane W English, Douglas Manuel, Carl Van Walraven, Monica Taljaard, Greg A Knoll

Open access · goldAbstract read
In one paragraph

Article in Canadian journal of kidney health and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Anne TsampalierosClinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada.ORCID https://orcid.org/0000-0001-8361-4419
Dean FergussonClinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada.
Stephanie DixonDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada.
Shane W EnglishClinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada.
Douglas ManuelDepartment of Family Medicine, University of Ottawa, ON, Canada.
Carl Van WalravenClinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada.
Monica TaljaardClinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada.
Greg A KnollClinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada.
University of Ottawa · CAChildren's Hospital of Eastern Ontario · CAOttawa Hospital · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney transplantation is the optimal treatment for patients with end-stage renal disease; however, long-term outcomes remain suboptimal.

objectiveThe objectives of our study were to examine the variation in survival rates and determine whether center volume and case mix are associated with transplant outcomes and explain the variation across kidney transplant centers in Ontario, Canada.

designThis was a population-based cohort study using health care administrative databases.

settingA total of 5 transplant centers across Ontario, Canada. PATIENTS: We included adults (≥18 years) undergoing primary, solitary kidney transplantation between January 1, 2000 to December 31, 2013. MEASUREMENTS: The co-primary outcomes were death-censored graft loss and total mortality.

methodsMultivariable Cox proportional hazards regression was used to assess potential associations and describe variation, using hazard ratios (HRs) with 95% confidence intervals (CIs) for each center relative to the average across all centers.

resultsThe study cohort included 5037 patients followed for a median of 5.3 years, interquartile range (2.7-8.6). In multivariable models, recipient age, body mass index, Charlson Index, time on dialysis, donor type, and age were found to be significantly associated with death-censored graft loss, and recipient age and sex, Charlson Index, time on dialysis, donor age, and time era of transplant were associated with total mortality. There was statistically significant variation across centers observed for death-censored graft loss ( LIMITATIONS: This study was limited by the small number of centers included.

conclusionsOutcomes differ across the 5 transplant centers in Ontario. We did not find any strong support for our hypotheses that case mix or center volume is responsible for these differences.

Indexed as

center variationgraft losskidney transplantationtotal mortality

Identifiers

PMID31565233
PMCPMC6755637
OpenAlexW2974459048

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.