Evidence map›Paper›PMID 31565197›Full record

ArticleOncology reviews2019

Therapeutic options for ampullary carcinomas. A review.

Dileep Kumar Reddy Regalla, Rojymon Jacob, Ashish Manne, Ravi Kumar Paluri

Open access · goldAbstract read
In one paragraph

Article in Oncology reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Histologic subtyping of ampullary carcinoma for targeted therapy.Journal of pathology and translational medicine · 2021
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dileep Kumar Reddy RegallaInternal Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL.
Rojymon JacobRadiation Oncology, University of Alabama at Birmingham Hospital, Birmingham, AL.
Ashish ManneMedical Oncology, University of South Alabama Hospital, Mobile, AL.
Ravi Kumar PaluriHematology-Oncology, University of Alabama at Birmingham Hospital, Birmingham, AL, USA.
John H. Stroger, Jr. Hospital of Cook County · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ampullary Carcinoma arises from a histologically heterogeneous region where three different epithelia converge. Even though Ampullary Carcinoma has a superior prognosis compared to pancreatic and biliary ductal neoplasms, at least half of the patients turn up at an advanced stage that limits the treatment prospects. In addition to surgery for early-stage disease, several studies have shown that chemoradiotherapy confers additional benefits in the management of Ampullary Carcinoma. Analogously, chemotherapy plays a crucial role in treating advanced Ampullary Carcinoma with distant metastasis/recurrences. Although, stage of the disease, lymph node status, and histo-morphology are three critical prognostic variables, recently much attention is being placed on the genetic landscape of Ampullary Carcinoma. In this review, we have discussed various studies describing the role of chemoradiation and chemotherapy in the treatment of early and advanced stage Ampullary Carcinoma. Also, we have summarized the molecular landscape of Ampullary Carcinoma and the novel therapeutic strategies which could possibly target the genetic alterations involving the tumor cells.

Indexed as

Ampullary carcinomachemoradiationchemotherapymolecular landscape

Identifiers

PMID31565197
PMCPMC6747019
OpenAlexW2972543689

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.