Evidence map›Paper›PMID 31565184›Full record

ArticleOncotarget2019

Consuming cholera toxin counteracts age-associated obesity.

Bernard J Varian, Theofilos Poutahidis, Gordon Haner, Alex Hardas, Vanessa Lau, Susan E Erdman

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Bernard J VarianDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Theofilos PoutahidisDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Gordon HanerDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Alex HardasDepartment of infectious Diseases and Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 54124, Greece.
Vanessa LauDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Susan E ErdmanDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Massachusetts Institute of Technology · USAristotle University of Thessaloniki · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the past forty years there has been an inexplicable increase in chronic inflammatory disorders, including obesity. One theory, the 'hygiene hypothesis', involves dysregulated immunity arising after too few beneficial early life microbe exposures. Indeed, earlier studies have shown that gut microbe-immune interactions contribute to smoldering inflammation, adiposity, and weight gain. Here we tested a safe and well-established microbe-based immune adjuvant to restore immune homeostasis and counteract inflammation-associated obesity in animal models. We found that consuming

Indexed as

body weightCLSexotoxin subunit Binflammationmouse

Identifiers

PMID31565184
PMCPMC6756858
OpenAlexW2979545305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.