Evidence map›Paper›PMID 31565151›Full record

ArticleOxidative medicine and cellular longevity2019

CD28 Deficiency Ameliorates Blast Exposure-Induced Lung Inflammation, Oxidative Stress, Apoptosis, and T Cell Accumulation in the Lungs via the PI3K/Akt/FoxO1 Signaling Pathway.

Yunen Liu, Changci Tong, Ying Xu, Peifang Cong, Ying Liu, Lin Shi, Xiuyun Shi, Yan Zhao, Guangyuan Bi, Hongxu Jin and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 34 citations in OpenAlex.

  1. Establishment and evaluation of anFrontiers in public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yunen LiuEmergency Medicine, Department of General Hospital of Northern Theater Command, Laboratory of Rescue Center of Severe Trauma PLA, No. 83 Road, Shenhe District, Shenyang l10016, China.ORCID https://orcid.org/0000-0001-8761-2402
Changci TongEmergency Medicine, Department of General Hospital of Northern Theater Command, Laboratory of Rescue Center of Severe Trauma PLA, No. 83 Road, Shenhe District, Shenyang l10016, China.
Ying XuRadiation Oncology, Department of General Hospital of Northern Theater Command, Shenyang l10016, China.
Peifang CongEmergency Medicine, Department of General Hospital of Northern Theater Command, Laboratory of Rescue Center of Severe Trauma PLA, No. 83 Road, Shenhe District, Shenyang l10016, China.
Ying LiuEmergency Medicine, Department of General Hospital of Northern Theater Command, Laboratory of Rescue Center of Severe Trauma PLA, No. 83 Road, Shenhe District, Shenyang l10016, China.
Lin ShiEmergency Medicine, Department of General Hospital of Northern Theater Command, Laboratory of Rescue Center of Severe Trauma PLA, No. 83 Road, Shenhe District, Shenyang l10016, China.
Xiuyun ShiEmergency Medicine, Department of General Hospital of Northern Theater Command, Laboratory of Rescue Center of Severe Trauma PLA, No. 83 Road, Shenhe District, Shenyang l10016, China.
Yan ZhaoInstitute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China.
Guangyuan BiMedical Service Department, Joint Service College of National Defense University, PLA 23rd, Taiping Road, Haitian District, Beijing 100858, China.ORCID https://orcid.org/0000-0002-2998-9583
Hongxu JinEmergency Medicine, Department of General Hospital of Northern Theater Command, Laboratory of Rescue Center of Severe Trauma PLA, No. 83 Road, Shenhe District, Shenyang l10016, China.ORCID https://orcid.org/0000-0003-2593-0995
Mingxiao HouEmergency Medicine, Department of General Hospital of Northern Theater Command, Laboratory of Rescue Center of Severe Trauma PLA, No. 83 Road, Shenhe District, Shenyang l10016, China.ORCID https://orcid.org/0000-0001-6865-7007
General Hospital of Shenyang Military Region · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although CD28 is associated with the expression of inflammatory mediators, apoptosis-related protein, immunosuppression, and tumorigenesis, the effects of CD28 deficiency on blast exposure-induced lung injury have not been investigated. In this study, we have explored the effects of CD28 on blast exposure-induced lung injury and studied its potential molecular mechanisms. A mouse model of blast exposure-induced acute lung injury was established. Sixty C57BL/6 wild-type (WT) and CD28 knockout (CD28

Indexed as

AnimalsApoptosisBlast InjuriesCD28 AntigensForkhead Box Protein O1MaleMiceMice, Inbred C57BLMice, KnockoutOxidative StressPhosphatidylinositol 3-KinasesPneumoniaProto-Oncogene Proteins c-aktRandom AllocationSignal TransductionT-LymphocytesCD28 AntigensForkhead Box Protein O1Foxo1 protein, mousePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-akt

Identifiers

PMID31565151
PMCPMC6745179
OpenAlexW2971887001

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.