Evidence map›Paper›PMID 31565102›Full record

ArticleDisease markers2019

Clinical Profiles of Selected Biomarkers Identifying Infection and Cancer Patients: A Gorzów Hospital Example.

Katarzyna Brzeźniakiewicz-Janus, Marcus Daniel Lancé, Andrzej Tukiendorf, Mirosław Franków, Joanna Rupa-Matysek, Edyta Wolny-Rokicka, Lidia Gil

Abstract read
In one paragraph

Article in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katarzyna Brzeźniakiewicz-JanusDepartment of Hematology, Multi-Specialist Hospital Gorzów Wielkopolski, Faculty of Medicine and Health Science, University of Zielona Góra, Gorzów Wielkopolski, Poland.
Marcus Daniel LancéDepartment of Anesthesiology, Intensive Care Unit and Perioperative Medicine, Hamad Medical Corporation, Doha, Qatar.
Andrzej TukiendorfDepartment of Public Health, Wrocław Medical University, Wrocław, Poland.ORCID https://orcid.org/0000-0001-5278-989X
Mirosław FrankówDepartment of Hematology, Multi-Specialist Hospital Gorzów Wielkopolski, Faculty of Medicine and Health Science, University of Zielona Góra, Gorzów Wielkopolski, Poland.
Joanna Rupa-MatysekDepartment of Hematology and Bone Marrow Transplantation, Poznań University of Medical Sciences, Poznań, Poland.
Edyta Wolny-RokickaDepartment of Surgery and Oncology, Multi-Specialist Hospital Gorzów Wielkopolski, Faculty of Medicine and Health Science, University of Zielona Góra, Gorzów Wielkopolski, Poland.ORCID https://orcid.org/0000-0002-9592-6433
Lidia GilDepartment of Hematology and Bone Marrow Transplantation, Poznań University of Medical Sciences, Poznań, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMany pathobiological processes that manifest in a patient's organs could be associated with biomarker levels that are detectable in different human systems. However, biomarkers that promote early disease diagnosis should not be tested only in personalized medicine but also in large-scale diagnostic evaluations of patients, such as for medical management.

objectiveWe aimed to create an easy algorithmic risk assessment tool that is based on obtainable "everyday" biomarkers, identifying infection and cancer patients. PATIENTS: We obtained the study data from the electronic medical records of 517 patients (186 infection and 331 cancer episodes) hospitalized at Gorzów Hospital, Poland, over a one and a half-year period from the 1 METHODS AND

resultsA set of consecutive statistical methods (cluster analysis, ANOVA, and ROC analysis) was used to predict infection and cancer. For in-hospital diagnosis, our approach showed independent clusters of patients by age, sex, MPV, and disease fractions. From the set of available "everyday" biomarkers, we established the most likely bioindicators for infection and cancer together with their classification cutoffs.

conclusionsDespite infection and cancer being very different diseases in their clinical characteristics, it seems possible to discriminate them using "everyday" biomarkers and popular statistical methods. The estimated cutoffs for the specified biomarkers can be used to allocate patients to appropriate risk groups for stratification purposes (medical management or epidemiological administration).

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AdolescentAdultAgedAged, 80 and overBiomarkers, TumorChildChild, PreschoolCommunicable DiseasesFemaleHumansInfantMaleMiddle AgedModels, StatisticalNeoplasmsSensitivity and SpecificityBiomarkers, Tumor

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PMID31565102
PMCPMC6745159

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.