ArticleOpen access rheumatology : research and reviews2019
A Swedish register-based, long-term inception cohort study of patients with rheumatoid arthritis - results of clinical relevance.
Article in Open access rheumatology : research and reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
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Who cites it
20 citing papers in PubMed.
- Radiographic outcome over 15 years in patients with early rheumatoid arthritis - a BARFOT-study.BMC rheumatology · 2026Article
- Empowerment as the key to health-enhancing physical activity in patients with rheumatoid arthritis and low physical function-a cross-sectional study.Clinical rheumatology · 2026Article
- Observational
- Physical and mental disability is evident 8 years after diagnosis in early rheumatoid arthritis despite contemporary medication and non-pharmacological interventions.Clinical rheumatology · 2025Article
- Autoantibodies to joint-related peptides as predictive markers in early rheumatoid arthritis.Rheumatology (Oxford, England) · 2025Article
- Article
- High leptin levels in blood are associated with chronic widespread pain in rheumatoid arthritis.Arthritis research & therapy · 2024Article
- Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice.The Journal of experimental medicine · 2023Article
- Osteoporosis-related fractures in men and women with established and early rheumatoid arthritis: predictors and risk compared with the general population.BMC rheumatology · 2023Article
- Article
- Article
- Erosion-free rheumatoid arthritis: clinical and conceptional implications-a BARFOT study.BMC rheumatology · 2022Article
- Comparison of chronic widespread pain prevalence with different criteria in two cohorts of rheumatoid arthritis.Clinical rheumatology · 2022Article
- Misdiagnosis of Rheumatoid Arthritis in a Long-Term Cohort of Early Arthritis Based on the ACR-1987 Classification Criteria.Open access rheumatology : research and reviews · 2022Article
- Pathomechanisms of bone loss in rheumatoid arthritis.Frontiers in medicine · 2022Review
- Patient Empowerment and Associations with Disease Activity and Pain-Related and Lifestyle Factors in Patients With Rheumatoid Arthritis.ACR open rheumatology · 2021Article
- Higher levels of anti-phosphorylcholine autoantibodies in early rheumatoid arthritis indicate lower risk of incident cardiovascular events.Arthritis research & therapy · 2021Article
- Distribution of erosions in hands and feet at the time for the diagnosis of RA and during 8-year follow-up.Clinical rheumatology · 2021Article
- Influence of Age and Sex on Disease Course and Treatment in Rheumatoid Arthritis.Open access rheumatology : research and reviews · 2021Article
- More Unnecessary Imaginary Worlds - Part 1: The Institute for Clinical and Economic Review's Evidence Report on Janus Kinase (JAK) Inhibitors in Rheumatoid Arthritis.Innovations in pharmacy · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAt the end of the twentieth century, the outcome of rheumatoid arthritis (RA) was shown to be unsatisfactory and new therapeutic strategies were introduced. This initiated a register-based long-term study of early RA, the Better Anti-Rheumatic PharmacOTherapy (BARFOT) study. The aims were to evaluate the disease course and to acquire knowledge for improved care. PATIENTS AND
methodsBARFOT is a multicentre observational study of patients with early RA, consecutively included 1992-2006. The patients are followed in daily practice according to a structured protocol for 15 years and data recorded in a web-based register. Also, through linkage of the BARFOT register to national registers we have acquired information on comorbidity and mortality.
resultsIn all, 2857 patients have been included and over 80 scientific articles have been published. Phenotypic characteristics at disease onset, i.e. gender, smoking habits and autoantibody profiles have been addressed. The disease course over 15 years was described. Early predictors for persistent disease activity, impaired function, joint damage and co-morbidities have been identified. Treatment strategies have been studied. A randomized sub-study gave strong support for the treatment of recent RA with low-dose prednisolone in combination with disease-modifying anti-rheumatic drug. Furthermore, the impact of lifestyle factors, such as smoking, alcohol consumption, body weight and physical activity has been addressed.
conclusionA register-based study like BARFOT has provided a basis for optimal long-term management of patients with RA. In addition, the register has made it possible to perform a diversity of studies of RA addressing various issues of major relevance to the patients.
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