ArticleInfection and drug resistance2019
Coagulative biomarkers on admission to the ICU predict acute kidney injury and mortality in patients with septic shock caused by intra-abdominal infection.
Article in Infection and drug resistance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Prolonged activated partial thromboplastin time predicts poor short-term prognosis in patients with acute pancreatitis: A retrospective cohort study.Clinical and translational science · 2022Trial
- Disseminated intravascular coagulation in chimeric antigen receptor T-cell therapy: a 6-year nationwide analysis of clinical outcomes and health care resource utilization in patients with hematologic malignancies.Research and practice in thrombosis and haemostasis · 2026Article
- Sepsis induced coagulopathy (SIC): is it monolithic?Thrombosis journal · 2026Article
- Development and Validation of a Nomogram for Predicting Acute Kidney Injury in Acute Respiratory Distress Syndrome.Journal of inflammation research · 2026Article
- Article
- Clinical and microbiological characteristics of bacteremia in pediatric intensive care unit: a retrospective analytical observational study.BMC pediatrics · 2025Observational
- Machine learning model for early prediction of acute kidney injury in heatstroke patients based on the first 24 h hospitalization data.Scientific reports · 2025Article
- Clinical value of combined detection of procalcitonin, D-dimer and fibrinogen in the evaluation of children with sepsis.Pakistan journal of medical sciences · 2025Article
- Urine pH is associated with the development of acute kidney injury in crush syndrome.Scientific reports · 2025Article
- Constructing an early warning model for elderly sepsis patients based on machine learning.Scientific reports · 2025Article
- Circulating T-lymphocyte subsets as promising biomarkers for the identification of sepsis-induced acute kidney injury.Journal of the Chinese Medical Association : JCMA · 2024Article
- An early warning model for predicting major adverse kidney events within 30 days in acute pancreatitis patients.Renal failure · 2024Article
- Development and external validation of a nomogram for the early prediction of acute kidney injury in septic patients: a multicenter retrospective clinical study.Renal failure · 2024Article
- The Relationship Between Acute Kidney Injury in Sepsis Patients and Coagulation Dysfunction and Prognosis.Open access emergency medicine : OAEM · 2024Article
- Association between early coagulation disorders and the risk of severe acute kidney injury in traumatic brain injury patients: a retrospective cohort study using the MIMIC-IV database.Frontiers in neurology · 2024Article
- Disseminated intravascular coagulation is strongly associated with severe acute kidney injury in patients with septic shock.Annals of intensive care · 2023Article
- Prognostic value of APTT combined with fibrinogen and creatinine in predicting 28-Day mortality in patients with septic shock caused by acute enteric perforation.BMC surgery · 2023Observational
- The association of coagulation indicators with in-hospital acute kidney injury and malignant events of patients with acute aortic dissection: a retrospective cohort study.Journal of thoracic disease · 2023Article
- The early diagnosis and pathogenic mechanisms of sepsis-related acute kidney injury.Open life sciences · 2023Review
- Construction and validation of an early warning model for predicting the acute kidney injury in elderly patients with sepsis.Aging clinical and experimental research · 2022Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSepsis-associated coagulopathy (SAC) contributes to the development of multiple organ failure (MOF) and increasing mortality. The present study was conducted to investigate whether coagulative biomarkers on admission to the intensive care unit (ICU) can predict acute kidney injury (AKI) and mortality in patients with septic shock caused by intra-abdominal infection (IAI). PATIENTS AND
methodsAn observational retrospective study was conducted in the surgical ICU. We studied patients who met the criteria of septic shock (Sepsis-3) caused by IAI between January 1, 2013, and December 31, 2016. By adjusting for baseline characteristics, multivariate regression analyses were employed to identify independent risk factors for predicting AKI and mortality.
resultsOf the 138 enrolled patients, 65 patients developed AKI. The patients who developed AKI exhibited a dramatically higher Sequential Organ Failure Assessment (SOFA) score (median, 12), Acute Physiology and Chronic Health Evaluation (APACHE) II score (median, 27.5) and mortality rate. In both models, we found that activated partial thromboplastin time (APTT) (odds ratio (OR)=1.074, 95% confidence interval (CI) 1.030-1.120,
conclusionIn patients with septic shock caused by IAI, APTT, PT and D-dimer level on admission to the ICU were significantly associated with AKI. Furthermore, APTT was an independent predictor of 30-day mortality.
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