ArticleNeuropsychiatric disease and treatment2019
Borderline personality disorder, trauma, and the hypothalamus-pituitary-adrenal axis.
Article in Neuropsychiatric disease and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Psychological trauma as a transdiagnostic risk factor for mental disorder: an umbrella meta-analysis.European archives of psychiatry and clinical neuroscience · 2023Pooled it
- Early life trauma and endometriosis: A case-control study on type and timing of adverse experiences.Archives of women's mental health · 2026Article
- Emerging trends and clinical challenges in AI-enhanced emotion diagnosis using physiological data.Medical & biological engineering & computing · 2026Review
- Review
- The Association Between Borderline Personality Disorder Symptoms and Social Behaviour Among University Students.Medicina (Kaunas, Lithuania) · 2025Article
- Borderline personality: revisiting its classification as a neurodevelopmental disorder.Frontiers in psychiatry · 2025Review
- Personality and Psychoneuroimmunology: A Systems Biology Perspective.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Article
- Borderline personality disorder: a comprehensive review of diagnosis and clinical presentation, etiology, treatment, and current controversies.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Personality andFrontiers in genetics · 2024Article
- Neural correlates of social exclusion and overinclusion in patients with borderline personality disorder: an fMRI study.Borderline personality disorder and emotion dysregulation · 2023Article
- Auricular Vagus Nerve Stimulation Improves Visceral Hypersensitivity and Gastric Motility and Depression-like Behaviors via Vago-Vagal Pathway in a Rat Model of Functional Dyspepsia.Brain sciences · 2023Article
- Article
- Reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder.Frontiers in psychiatry · 2022Article
- Menstrual Cycle in Trauma-Related Disorders: A Mini-Review.Frontiers in global women's health · 2022Review
- Molecular impacts of childhood abuse on the human brain.Neurobiology of stress · 2021Review
- [Disease burden of borderline personality disorder: cost of illness, somatic comorbidity and mortality].Der Nervenarzt · 2021Review
- Diazepam ameliorates altered proinflammatory and cardiac markers in stress exposed rats.Saudi journal of biological sciences · 2021Article
- Understanding the Relationship Between Sleep Problems in Early Childhood and Borderline Personality Disorder: A Narrative Review.Nature and science of sleep · 2021Review
- Chronic Pain and Psychiatric Conditions.Complex psychiatryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Borderline personality disorder (BPD) is a complex psychiatric illness for which treatment poses a significant challenge due to limited effective pharmacologic treatments, and under-resourced psychological interventions. BPD is one of the most stigmatized conditions in psychiatry today, but can be understood as a modifiable, neurodevelopmental disorder that arises from maladaptive responses to trauma and stress. Stress susceptibility and reactivity in BPD is thought to mediate both the development and maintenance of BPD symptomatology, with trauma exposure considered an early life risk factor of development, and acute stress moderating symptom trajectory. An altered stress response has been characterized in BPD at the structural, neural, and neurobiological level, and is believed to underlie the maladaptive behavioral and cognitive symptomatology presented in BPD. The endocrine hypothalamus-pituitary-adrenal (HPA) axis represents a key stress response system, and growing evidence suggests it is dysfunctional in the BPD patient population. This theoretical review examines BPD in the context of a neurodevelopmental stress-related disorder, providing an overview of measurements of stress with a focus on HPA-axis measurement. Potential confounding factors associated with measurement of the HPA system are discussed, including sex and sex hormones, genetic factors, and the influence of sample collection methods. HPA-axis dysfunction in BPD largely mirrors findings demonstrated in post-traumatic stress disorder and may represent a valuable neuroendocrine target for diagnostic or treatment response biomarkers, or for which novel treatments can be investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.