ArticleInternational journal of nanomedicine2019
Temperature and pH-responsive nano-hydrogel drug delivery system based on lysine-modified poly (vinylcaprolactam).
Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 80 citations in OpenAlex.
- Temperature/pH Dual-Responsive Hydrogels: Research Progress in Preparation Methods, Structural Design Strategies and Biomedical Applications.Gels (Basel, Switzerland) · 2026Review
- Lab-on-a-Chip and Microfluidics Technologies for Nano Drug Delivery.Bioengineering (Basel, Switzerland) · 2026Review
- Bio-Polymers Based Functionalized Hydrogel Carriers for Targeted Oncology Therapies: Current Progress and Future Perspectives.International journal of nanomedicine · 2026Review
- pH-Responsive Modified Dextran Nanogel for Liver Targeted Doxorubicin Delivery.Gels (Basel, Switzerland) · 2025Article
- Regulating Intratumoral Fungi With Hydrogels: A Novel Approach to Modulating the Tumor Microbiome for Cancer Therapy.Cancer medicine · 2025Review
- Temperature- and pH-Responsive Poly(NIPAM-Gels (Basel, Switzerland) · 2025Article
- A Comprehensive Review of Current Approaches in Bladder Cancer Treatment.ACS pharmacology & translational science · 2025Review
- Recent Advancements in Nanopharmaceuticals for Novel Drug Delivery Systems.Pharmaceutical nanotechnology · 2025Review
- Endosomal pH, Redox Dual-Sensitive Prodrug Micelles Based on Hyaluronic Acid for Intracellular Camptothecin Delivery and Active Tumor Targeting in Cancer Therapy.Pharmaceutics · 2024Article
- Anti-cancer activity of zinc-tetraphenylporphyrin photosensitizer/dextran-RSC advances · 2024Article
- Stimuli-responsive hydrogel based on natural polymers for breast cancer.Frontiers in chemistry · 2024Review
- Commercial hydrogel product for drug delivery based on route of administration.Frontiers in chemistry · 2024Review
- Innovative Design of Targeted Nanoparticles: Polymer-Drug Conjugates for Enhanced Cancer Therapy.Pharmaceutics · 2023Review
- pH and Thermoresponsive PNIPAm-co-Polyacrylamide Hydrogel for Dual Stimuli-Responsive Controlled Drug Delivery.Polymers · 2022Article
- Magneto-Mechanically Triggered Thick Films for Drug Delivery Micropumps.Nanomaterials (Basel, Switzerland) · 2022Article
- Advances of Hydrogel Therapy in Periodontal Regeneration-A Materials Perspective Review.Gels (Basel, Switzerland) · 2022Review
- Nanotechnology in drug and gene delivery.Naunyn-Schmiedeberg's archives of pharmacology · 2022Review
- The inhibitory effect of curcumin loaded poly (vinyl caprolactam) nanohydrogel on insulin fibrillation.Process biochemistry (Barking, London, England) · 2022Article
- In vitro DNA plasmid condensation and transfection through pH-responsive nanohydrogel.Progress in biomaterials · 2022Article
- A Review on Current Designation of Metallic Nanocomposite Hydrogel in Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSmart materials capable of responding to external stimuli are noteworthy candidates in designing drug delivery systems. In many of the recent research, temperature and pH have been recognized as the main stimulating factors in designing systems for anti-cancer drugs delivery systems. PURPOSE: In this study, thermo and pH-responsive character of a nano-carrier drug delivery platform based on lysine modified poly (vinylcaprolactam) hydrogel conjugated with doxorubicin was assessed.
methodsPoly (vinylcaprolactam) cross-linked with poly (ethyleneglycol) diacrylate was prepared via RAFT polymerization, and the prepared structure was linked with lysine through ring-opening. The anti-cancer drug doxorubicin, was linked to lysine moiety of the prepared structure via Schiff-base reaction. The prepared platform was characterized by
conclusionAccording to the results, well-structure defined smart pH and temperature responsive nano-hydrogel was prepared. The enhanced release rates are observed at acidic pH and elevated temperature. We have concluded that the doxorubicin-conjugated nanoparticle results in higher cellular uptakes and more cytotoxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.