Evidence map›Paper›PMID 31564760›Full record

ArticleJournal of the American Statistical Association2019

Inverse probability weighted estimation of risk under representative interventions in observational studies.

Jessica G Young, Roger W Logan, James M Robins, Miguel A Hernán

Abstract read
In one paragraph

Article in Journal of the American Statistical Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Observational
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jessica G YoungDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute.
Roger W LoganDepartment of Epidemiology, Harvard T.H. Chan School of Public Health.
James M RobinsDepartment of Epidemiology, Department of Biostatistics, Harvard T.H. Chan School of Public Health.
Miguel A HernánDepartment of Epidemiology, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard-MIT Division of Health Sciences and Technology.

Funding

Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Risk Factors for Ischemic Stroke in WomenR01HL088521 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REXRODE, KATHRYN M · 2008 to 2025
$9.9M
Comprehensive Translational Science Analytics Tools for the Global Health AgendaDP1ES025459 · NIEHS · YALE UNIVERSITY · PI SPIEGELMAN, DONNA L · 2014 to 2018
$4.1M
Estimating Effects of Interventions in Longitudinal DataR01HL080644 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HERNAN, MIGUEL · 2005 to 2013
$4.0M
New Methods for the design and evaluation of large HIV prevention interventionsR01AI112339 · NIAID · YALE UNIVERSITY · PI SPIEGELMAN, DONNA L · 2014 to 2017
$2.7M
Qiagen PyroMark Q96 MD Automated Pyrosequencing SystemS10RR027271 · NCRR · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GROUDINE, MARK T · 2011 to 2011
$142k
NCI NIH HHS UM1 CA186107NCRR NIH HHS S10 RR027271NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL080644NHLBI NIH HHS R01 HL088521NIAID NIH HHS R01 AI112339NIEHS NIH HHS DP1 ES025459
6 · The paper itself

Abstract

Researchers are often interested in using observational data to estimate the effect on a health outcome of maintaining a continuous treatment within a pre-specified range over time; e.g. "always exercise at least 30 minutes per day". There may be many precise interventions that could achieve this range. In this paper we consider representative interventions. These are special cases of random dynamic interventions; interventions under which treatment at each time is assigned according to a random draw from a distribution that may depend on a subject's measured past. Estimators of risk under representative interventions on a time-varying treatment have previously been described based on g-estimation of structural nested cumulative failure time models. In this paper, we consider an alternative approach based on inverse probability weighting (IPW) of marginal structural models. In particular, we show that the risk under a representative intervention on a time-varying continuous treatment can be consistently estimated via computationally simple IPW methods traditionally used for deterministic static (i.e. "nonrandom" and "nondynamic") interventions for binary treatments. We present an application of IPW in this setting to estimate the 28-year risk of coronary heart disease under various representative interventions on lifestyle behaviors in the Nurses Health Study.

Indexed as

causal inferenceg-formulalongitudinal datamarginal structural modelssurvival analysis

Identifiers

PMID31564760
PMCPMC6764781

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.