Raising the Bar On-Bead: Efficient On-Resin Synthesis of α-Conotoxin LvIA.

Thilini D Kondasinghe, Hasina Y Saraha, Shane T Jackowski, Jennifer L Stockdill

Abstract read

In one paragraph

Article in Tetrahedron letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.6field-weighted citation impact, top 33% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration.Molecules (Basel, Switzerland) · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Thilini D KondasingheDepartment of Chemistry, Wayne State University, Detroit, MI 48202.

Hasina Y SarahaDepartment of Chemistry, Wayne State University, Detroit, MI 48202.

Shane T JackowskiDepartment of Chemistry, Wayne State University, Detroit, MI 48202.

Jennifer L StockdillDepartment of Chemistry, Wayne State University, Detroit, MI 48202.ORCID 0000-0003-4238-6530

Wayne State University · US

Funding

C-N Bond-Forming Methodologies for the Synthesis of Small Molecules and PeptidesR00GM097095 · NIGMS · WAYNE STATE UNIVERSITY · PI STOCKDILL, JENNIFER LYNN · 2012 to 2014

$837k

NIGMS NIH HHS R00 GM097095

6 · The paper itself

Abstract

α4/7-Conotoxin LvIA is an isoform-selective inhibitor of the α3β2 nicotinic acetylcholine receptor. An efficient strategy for the synthesis of this toxin is critical to advancing its utility as a probe for receptor function and as a potential pharmaceutical lead target. On-resin methods for peptide synthesis offer potential synthetic advantages; however, strategies for on-resin formation of multiple disulfides have historically been low-yielding. Here, we harness the reactivity of the Allocam protecting group and employ 3-amino acid spacer strategy to synthesize α4/7-conotoxin LvIA via three different on-resin strategies, each of which results in an isolated yield higher than prior fully on-resin approaches.

Identifiers

PMID31564757

DOI10.1016/j.tetlet.2018.11.048

PMCPMC6764457

OpenAlexW2901550662

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.