Evidence map›Paper›PMID 31564651›Full record

ArticleReproductive biomedicine online2019

Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction.

Nerea Martín-Calvo, Lidia Mínguez-Alarcón, Audrey J Gaskins, Feiby L Nassan, Paige L Williams, Irene Souter, Russ Hauser, Jorge E Chavarro, EARTH Study team

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In one paragraph

Article in Reproductive biomedicine online, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Sharing the motherload: A review and development of the CO-Parent conceptual model for early childhood obesity prevention.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Nerea Martín-CalvoUniversity of Navarra, Department of Preventive Medicine and Public Health, Instituto de Investigación Sanitaria de Navarra (IdISNA), Pamplona, Spain; CIBER Physiopathology of Obesity and Nutrition (CIBERobn), Carlos III Institute of Health, Madrid, Spain.
Lidia Mínguez-AlarcónDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston MA, USA.
Audrey J GaskinsDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 25 Shattuck Street, Boston MA, USA; Department of Epidemiology, University of Emory. Atlanta GA, USA.
Feiby L NassanDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston MA, USA.
Paige L WilliamsDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA.
Irene SouterVincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA.
Russ HauserDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA; Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA.
Jorge E ChavarroDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 25 Shattuck Street, Boston MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA. Electronic address: jchavarr@hsph.harvard.edu.
EARTH Study team

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
PCBs, Phthalates and Male Reproductive HealthR01ES009718 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HAUSER, RUSS B · 1999 to 2018
$11.6M
Maternal Exposure to Air Pollution and Early Pregnancy OutcomesR00ES026648 · NIEHS · EMORY UNIVERSITY · PI GASKINS, AUDREY JANE · 2019 to 2021
$730k
Maternal Exposure to Air Pollution and Early Pregnancy OutcomesK99ES026648 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI GASKINS, AUDREY JANE · 2017 to 2018
$246k
NICHD NIH HHS L50 HD085359NIDDK NIH HHS P30 DK046200NIEHS NIH HHS K99 ES026648NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R00 ES026648NIEHS NIH HHS R01 ES009718
6 · The paper itself

Abstract

research questionStudies in rodents have shown that paternal folate intake prior to conception is associated with pregnancy and offspring outcomes. The aim of this study was to assess whether those associations might apply to humans as well.

designBetween 2007 and 2017, the study prospectively analysed data from 108 couples participating in a preconception cohort of couples undergoing fertility treatment using their own gametes, whose treatment resulted in 113 pregnancies during the course of the study. Paternal and maternal preconception folate intake was assessed using a validated food frequency questionnaire. Linear mixed models were used to assess whether paternal preconception folate intake was associated with gestational age at delivery and gestational age-specific birthweight, while accounting for correlated data and potential confounders.

resultsIn a multivariable-adjusted model, a 400 μg/day increase in preconception paternal folate intake was associated with a 2.6-day longer gestation (95% confidence interval 0.8-4.3) after adjusting for potential confounders, including maternal folate intake. Similar associations were found for folate from food and supplements. Maternal folate intake was not associated with gestational age at delivery. Neither paternal nor maternal folate intake was associated with gestational-age-specific birthweight.

conclusionsHigher paternal preconception folate intake was associated with slightly longer gestation among live births achieved through assisted reproduction. The results suggest that preconception exposures of the father may have an impact on the health of his offspring, and therefore that preconception care should shift from a woman-centric to a couple-based approach.

Indexed as

Birth WeightDietary SupplementsFathersPreconception CareAdultFemaleFolic AcidGestational AgeHumansInfant, NewbornLive BirthMaleMultivariate AnalysisPregnancyProspective StudiesReproductive Techniques, AssistedFolic AcidGestational ageMaternal folateOffspring birthweightPaternal folate

Identifiers

PMID31564651
PMCPMC6848767

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.