ArticleAmerican journal of preventive medicine2019
An Examination of Concurrent Opioid and Benzodiazepine Prescribing in 9 States, 2015.
Article in American journal of preventive medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Application of a diazepam milligram equivalency algorithm to assess benzodiazepine dose intensity in Rhode Island in 2018.Journal of managed care & specialty pharmacy · 2022Pooled it
- Advances in prescription drug monitoring program research: a literature synthesis (June 2018 to December 2019).Current opinion in psychiatry · 2020Pooled it
- Trial
- Use of sedative drugs among adults reporting illicit opioid use or prescription opioid use in the United States, 2017-2024.Drug and alcohol dependence · 2026Article
- Trends in overdose deaths involving gabapentinoids and Z-drugs in the United States.Drug and alcohol dependence · 2023Article
- Characteristics of statewide prescription drug monitoring programs and potentially inappropriate opioid prescribing to patients with non-cancer chronic pain: A machine learning application.Preventive medicine · 2022Observational
- Opioid and Benzodiazepine Substitutes: Impact on Drug Overdose Mortality in Medicare Population.The American journal of medicine · 2022Article
- Concurrent Use of Prescription Opioids and Gabapentinoids in Older Adults.American journal of preventive medicine · 2022Article
- Prevalences of and characteristics associated with single- and polydrug-involved U.S. Emergency Department Visits in 2018.Addictive behaviors · 2022Article
- Benzodiazepine exposures among women of reproductive age in the US, 2004-2018.Human & experimental toxicology · 2021Article
- Association Between Receipt of Overlapping Opioid and Benzodiazepine Prescriptions From Multiple Prescribers and Overdose Risk.JAMA network open · 2021Article
- Opioid deaths involving concurrent benzodiazepine use: Assessing risk factors through the analysis of prescription drug monitoring data and postmortem toxicology.Drug and alcohol dependence · 2021Article
- Concurrent Utilization of Prescription Opioids and Non-opioid Controlled Substances: Rhode Island Prescription Drug Monitoring Program, 2018.Rhode Island medical journal (2013) · 2020Observational
- Limited Utility for Benzodiazepines in Chronic Pain Management: A Narrative Review.Advances in therapy · 2020Review
- Association of Medicare Part D Benzodiazepine Coverage Expansion With Changes in Fall-Related Injuries and Overdoses Among Medicare Advantage Beneficiaries.JAMA network open · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
introductionConcurrent prescribing of opioids and benzodiazepines is discouraged by evidence-based clinical guidelines because of the known risks of taking these medications in combination.
methodsThis study analyzed concurrent opioid and benzodiazepine prescribing in 9 states using the 2015 Prescription Behavior Surveillance System, a multistate database of de-identified prescription drug monitoring program data. Concurrent prescribing rates were examined among individuals with both an opioid and a benzodiazepine prescription. Among patients with concurrent prescribing, total days of opioid supply, daily dosage of opioids, and total days of concurrent prescriptions were examined. Analyses were stratified by whether concurrent prescribing was from a single prescriber or multiple prescribers. Opioid prescribing and concurrent opioid and benzodiazepine prescribing rates were examined by age and sex. Analyses were conducted in 2018.
resultsAmong 19,977,642 patients that were prescribed an opioid, 21.6% (4,324,092) were also prescribed a benzodiazepine, of which 54.9% (2,375,219) had concurrent prescriptions. More than half of patients with concurrent opioids and benzodiazepines received prescriptions from 2 or more distinct prescribers. Mean total opioid days, daily opioid dosage, and days of concurrent prescribing were higher among patients when multiple prescribers were involved compared with concurrent prescriptions from the same prescriber. Concurrent prescribing was more common among adults aged ≥50 years and female patients.
conclusionsPublic health interventions are needed to reduce concurrent prescribing of opioids and benzodiazepines. Evidence-based guidelines can help reduce concurrent prescribing when one prescriber is involved, and utilization of prescription drug monitoring programs and improved care coordination could help address concurrent prescribing when multiple prescribers are involved.
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