ArticleCurrent biology : CB2019
Spatiotemporally Asymmetric Excitation Supports Mammalian Retinal Motion Sensitivity.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Conservation of retinal direction-selective circuits across vertebrate species.Current opinion in genetics & development · 2026Review
- Machine learning discovers numerous new computational principles supporting elementary motion detection.Nature communications · 2026Article
- Unraveling the role of asymmetric excitatory and inhibitory synaptic inputs to retinal ganglion cell direction selectivity.Frontiers in neuroscience · 2026Article
- Functionally distinct GABAergic amacrine cell types regulate spatiotemporal encoding in the mouse retina.Nature neuroscience · 2025Article
- Asymmetries in the Architecture of ON and OFF Arbors in ON-OFF Direction-Selective Ganglion Cells.The Journal of comparative neurology · 2025Article
- Neural Circuits Underlying Multifeature Extraction in the Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells.eLife · 2023Article
- Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells.bioRxiv : the preprint server for biology · 2023Article
- Asymmetric connections with starburst amacrine cells underlie the upward motion selectivity of J-type retinal ganglion cells.PLoS biology · 2023Article
- A circuit suppressing retinal drive to the optokinetic system during fast image motion.Nature communications · 2023Article
- Asymmetric retinal direction tuning predicts optokinetic eye movements across stimulus conditions.eLife · 2023Article
- New insights into retinal circuits through EM connectomics: what we have learnt and what remains to be learned.Frontiers in ophthalmology · 2023Review
- Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina.Nature communications · 2022Article
- Classical center-surround receptive fields facilitate novel object detection in retinal bipolar cells.Nature communications · 2022Article
- ON than OFF pathway disruption leads to greater deficits in visual function and retinal dopamine signaling.Experimental eye research · 2022Article
- Conserved circuits for direction selectivity in the primate retina.Current biology : CB · 2022Article
- Distinct inhibitory pathways control velocity and directional tuning in the mouse retina.Current biology : CB · 2022Article
- Impaired motion perception is associated with functional and structural visual pathway damage in multiple sclerosis and neuromyelitis optica spectrum disorders.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Cholinergic feedback to bipolar cells contributes to motion detection in the mouse retina.Cell reports · 2021Article
- Spectral inference reveals principal cone-integration rules of the zebrafish inner retina.Current biology : CB · 2021Article
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3 authors.
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Abstract
The detection of visual motion is a fundamental function of the visual system. How motion speed and direction are computed together at the cellular level, however, remains largely unknown. Here, we suggest a circuit mechanism by which excitatory inputs to direction-selective ganglion cells in the mouse retina become sensitive to the motion speed and direction of image motion. Electrophysiological, imaging, and connectomic analyses provide evidence that the dendrites of ON direction-selective cells receive spatially offset and asymmetrically filtered glutamatergic inputs along motion-preference axis from asymmetrically wired bipolar and amacrine cell types with distinct release dynamics. A computational model shows that, with this spatiotemporal structure, the input amplitude becomes sensitive to speed and direction by a preferred direction enhancement mechanism. Our results highlight the role of an excitatory mechanism in retinal motion computation by which feature selectivity emerges from non-selective inputs.
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