Evidence map›Paper›PMID 31564164›Full record

ArticleHypertension (Dallas, Tex. : 1979)2019

ANO4 (Anoctamin 4) Is a Novel Marker of Zona Glomerulosa That Regulates Stimulated Aldosterone Secretion.

Carmela Maniero, Paolo Scudieri, Lalarukh Haris Shaikh, Wanfeng Zhao, Mark Gurnell, Luis J V Galietta, Morris J Brown

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. From Plastics to Prognosis:Diagnostics (Basel, Switzerland) · 2026
    Article
  3. TMEM16 proteins: CaInternational journal of molecular medicine · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Journal of personalized medicine · 2023
    Article
  9. Polymodal Control of TMEM16x Channels and Scramblases.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Review
  12. The CaActa pharmaceutica Sinica. B · 2021
    Review
  13. Prediction of Functional Consequences of Missense Mutations in ANO4 Gene.International journal of molecular sciences · 2021
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Carmela ManieroFrom the Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom Clinical Pharmacology Unit (C.M., L.H.S., M.J.B.).
Paolo ScudieriTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy (P.S., L.J.V.G.).
Lalarukh Haris ShaikhFrom the Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom Clinical Pharmacology Unit (C.M., L.H.S., M.J.B.).
Wanfeng ZhaoHuman Research Tissue Bank, Cambridge University, Hospitals NHS Foundation Trust, Addenbrooke's Hospital, United Kingdom (W.Z.).
Mark GurnellMetabolic Research Laboratories-Wellcome Trust-MRC Institute of Metabolic Science (M.G.).
Luis J V GaliettaTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy (P.S., L.J.V.G.).
Morris J BrownFrom the Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom Clinical Pharmacology Unit (C.M., L.H.S., M.J.B.).
Telethon Institute Of Genetics And Medicine · ITWilliam Harvey Research Institute · GBCambridge University Hospitals NHS Foundation Trust · GBWellcome/MRC Institute of Metabolic Science · GB

Funding

British Heart Foundation FS/11/35/28871British Heart Foundation FS/14/12/30540
6 · The paper itself

Abstract

Microarray comparison of the transcriptomes of human adrenal zona glomerulosa (ZG) and zona fasciculata found several ZG-specific genes that negatively regulate aldosterone secretion. The third and most significantly upregulated ZG-gene (19.9-fold compared with zona fasciculata,

Indexed as

Gene Expression RegulationAdrenal CortexAldosteroneAnalysis of VarianceAnoctaminsCell CommunicationCell ProliferationCells, CulturedFluorescent Antibody TechniqueHumansHyperaldosteronismHypertensionReal-Time Polymerase Chain ReactionSignal TransductionTissue Array AnalysisTissue Culture TechniquesAldosteroneAnoctaminsaldosteroneanoctaminscell proliferationchloride channelZona glomerulosa

Identifiers

PMID31564164
PMCPMC6791498
OpenAlexW2978305499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.