Evidence map›Paper›PMID 31564161›Full record

Observational studyHypertension (Dallas, Tex. : 1979)2019

Pregnancy-Related Acute Kidney Injury in Preeclampsia: Risk Factors and Renal Outcomes.

Frances I Conti-Ramsden, Hannah L Nathan, Annemarie De Greeff, David R Hall, Paul T Seed, Lucy C Chappell, Andrew H Shennan, K Bramham

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 5 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 85 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Frances I Conti-RamsdenFrom the Department of Women and Children's Health, King's College London, United Kingdom; (F.I.C-R., H.L.N., P.T.S., L.C.C., A.H.S., K.B.).
Hannah L NathanFrom the Department of Women and Children's Health, King's College London, United Kingdom; (F.I.C-R., H.L.N., P.T.S., L.C.C., A.H.S., K.B.).
Annemarie De GreeffAccuracy Assessed Medical Devices CC, Diamond, South Africa (A.D.g.).
David R HallDepartment of Obstetrics and Gynaecology, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa (D.R.H.).
Paul T SeedFrom the Department of Women and Children's Health, King's College London, United Kingdom; (F.I.C-R., H.L.N., P.T.S., L.C.C., A.H.S., K.B.).
Lucy C ChappellFrom the Department of Women and Children's Health, King's College London, United Kingdom; (F.I.C-R., H.L.N., P.T.S., L.C.C., A.H.S., K.B.).
Andrew H ShennanFrom the Department of Women and Children's Health, King's College London, United Kingdom; (F.I.C-R., H.L.N., P.T.S., L.C.C., A.H.S., K.B.).
K BramhamFrom the Department of Women and Children's Health, King's College London, United Kingdom; (F.I.C-R., H.L.N., P.T.S., L.C.C., A.H.S., K.B.).
King's College London · GB

Funding

Department of Health RP-2014-05-019Medical Research Council MR/N006240/1
6 · The paper itself

Abstract

Preeclampsia is a common cause of acute kidney injury (AKI) in low- and middle-income countries, but AKI incidence in preeclampsia, its risk factors, and renal outcomes are unknown. A prospective observational multicenter study of women admitted with preeclampsia in South Africa was conducted. Creatinine concentrations were extracted from national laboratory databases for women with maximum creatinine of ≥90 μmol/L (≥1.02 mg/dL). Renal injury and recovery were defined by Kidney Disease Improving Global Outcomes creatinine criteria. Predefined risk factors, maternal outcomes, and neonatal outcomes were compared between AKI stages. Of 1547 women admitted with preeclampsia 237 (15.3%) met AKI criteria: 6.9% (n=107) stage 1, 4.3% (n=67) stage 2, and 4.1% (n=63) stage 3. There was a higher risk of maternal death (n=7; relative risk, 4.3; 95% CI, 1.6-11.4) and stillbirth (n=80; relative risk, 2.2; 95% CI, 1.8-2.8) in women with AKI compared with those without. Perinatal mortality was also increased (89 of 240; 37.1%). Hypertension in a previous pregnancy was the strongest predictor of AKI stage 2 or 3 (odds ratio, 2.24; 95% CI, 1.21-4.17). Renal recovery rate reduced with increasing AKI stage. A third of surviving women (76 of 230 [33.0%]) had not recovered baseline renal function by discharge. Approximately half (39 of 76; 51.3%) of these women had no further creatinine testing post-discharge. In summary, AKI was common in women with preeclampsia and had high rates of associated maternal and perinatal mortality. Only two-thirds of women had confirmed renal recovery. History of a previous hypertensive pregnancy was an important risk factor.

Indexed as

Perinatal DeathAcute Kidney InjuryAdolescentAdultComorbidityConfidence IntervalsCreatinineDeveloping CountriesFemaleFollow-Up StudiesHospitalizationHumansInfant, NewbornKidney Function TestsMaternal DeathOdds RatioCreatinineacute kidney injurycreatininepreeclampsiapregnancyrenal insufficiency, chronic

Identifiers

PMID31564161
PMCPMC6791560
OpenAlexW2977481512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.