ArticleCellular and molecular life sciences : CMLS2020
The Drosophila odorant-binding protein 28a is involved in the detection of the floral odour ß-ionone.
Article in Cellular and molecular life sciences : CMLS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 47 citations in OpenAlex.
- Odorant-binding proteins and chemosensory proteins in insects: structural insights, functional plasticity, and prospects for targeted pest management.Molecular biology reports · 2026Review
- Adaptive Evolution of Odorant-Binding and Chemosensory Protein Gene Families in GenusBiomolecules · 2026Article
- Olfactory binding proteins: a review across the Insecta.Frontiers in zoology · 2025Review
- Antennal transcriptome analysis reveals sensory receptors potentially associated with host detection in the livestock pest Lucilia cuprina.Parasites & vectors · 2024Article
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- The Plant Volatile-Sensing Mechanism of Insects and Its Utilization.Plants (Basel, Switzerland) · 2024Review
- Neuronal expression in Drosophila of an evolutionarily conserved metallophosphodiesterase reveals pleiotropic roles in longevity and odorant response.PLoS genetics · 2023Article
- A Highly Expressed Antennae Odorant-Binding Protein Involved in Recognition of Herbivore-Induced Plant Volatiles inInternational journal of molecular sciences · 2023Article
- Stochastic Modeling of Gene Expression Evolution Uncovers Tissue- and Sex-Specific Properties of Expression Evolution in theJournal of computational biology : a journal of computational molecular cell biology · 2023Article
- Two Antenna-Enriched Odorant Binding Proteins in Dioryctria abietella Tuned to General Odorants and InsecticidesInsects · 2022Article
- Proteomic Characterization ofBiology · 2022Article
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- A Comparative Evaluation of the Structural and Dynamic Properties of Insect Odorant Binding Proteins.Biomolecules · 2022Article
- Review
- GOBP1 from the Variegated CutwormInsects · 2021Article
- Antennal Enriched Odorant Binding Proteins Are Required for Odor Communication inBiomolecules · 2021Article
- The 40-Year Mystery of Insect Odorant-Binding Proteins.Biomolecules · 2021Review
- Identification and functional characterization of odorant-binding proteins 69a and 76a ofHeliyon · 2021Article
- Expression Profiles and Functional Characterization of Chemosensory Protein 15 (HhalCSP15) in the Brown Marmorated Stink BugFrontiers in physiology · 2021Article
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10 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Odorant-binding proteins (OBPs) are small soluble proteins that are thought to transport hydrophobic odorants across the aqueous sensillar lymph to olfactory receptors. A recent study revealed that OBP28a, one of the most abundant Drosophila OBPs, is not required for odorant transport, but acts in buffering rapid odour variation in the odorant environment. To further unravel and decipher its functional role, we expressed recombinant OBP28a and characterized its binding specificity. Using a fluorescent binding assay, we found that OBP28a binds a restricted number of floral-like chemicals, including ß-ionone, with an affinity in the micromolar range. We solved the X-ray crystal structure of OBP28a, which showed extensive conformation changes upon ligand binding. Mutant flies genetically deleted for the OBP28a gene showed altered responses to ß-ionone at a given concentration range, supporting its essential role in the detection of specific compounds present in the natural environment of the fly.
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