ArticleThe Journal of infectious diseases2020
Adenoviral Infections in Singapore: Should New Antiviral Therapies and Vaccines Be Adopted?
Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Prevalence and Molecular Detection of Carbapenemase Genes in ClinicalInternational journal of microbiology · 2026Article
- Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies.Frontiers in immunology · 2025Article
- Human adenovirus type 4 (HAdV-4) associated acute respiratory tract infection in children & genetic characteristics of HAdV-4 in China: a prospective multicenter study.BMC infectious diseases · 2024Article
- Molecular characterization of human adenoviruses associated with pediatric respiratory infections in Karachi, Pakistan.BMC infectious diseases · 2024Article
- Genotypes and Phylogenetic Analysis of Human Adenovirus in Hospitalized Pneumonia and Influenza-Like Illness Patients in Jiangsu Province, China (2013-2021).Infection and drug resistance · 2024Article
- The changed endemic pattern of human adenovirus from species B to C among pediatric patients under the pressure of non-pharmaceutical interventions against COVID-19 in Beijing, China.Virology journal · 2023Article
- Prospective surveillance of human adenovirus in acute respiratory infections reveals epidemiological features and the disappearance of species B during the COVID-19 pandemic in Beijing, China.The Journal of infection · 2022Article
- Molecular Typing and Rapid Identification of Human Adenoviruses Associated With Respiratory Diseases Using Universal PCR and Sequencing Primers for the Three Major Capsid Genes: Penton Base, Hexon, and Fiber.Frontiers in microbiology · 2022Article
- Molecular typing of human adenoviruses among hospitalized patients with respiratory tract infections in a tertiary Hospital in Guangzhou, China between 2017 and 2019.BMC infectious diseases · 2021Article
- Seroprevalence of Neutralizing Antibodies against Six Human Adenovirus Types Indicates the Low Level of Herd Immunity in Young Children from Guangzhou, China.Virologica Sinica · 2021Article
- Construction and Characterization of a Novel Recombinant Attenuated and Replication-Deficient Candidate Human Adenovirus Type 3 Vaccine: "Adenovirus Vaccine Within an Adenovirus Vector".Virologica Sinica · 2021Article
- Patient hematology during hospitalization for viral pneumonia caused by SARS-CoV-2 and non-SARS-CoV-2 agents: a retrospective study.European journal of medical research · 2021Article
- Complete Genome Sequences of Two Human Adenovirus Type 55 Isolates from South Korea and the United States.Microbiology resource announcements · 2021Article
- Outbreak of severe acute respiratory infection in Southern Province, Sri Lanka in 2018: a cross-sectional study.BMJ open · 2020Article
- Genomics-based re-examination of the taxonomy and phylogeny of human and simian Mastadenoviruses: an evolving whole genomes approach, revealing putative zoonosis, anthroponosis, and amphizoonosis.Cladistics : the international journal of the Willi Hennig Society · 2020Article
- Virus detections among patients with severe acute respiratory illness, Northern Vietnam.PloS one · 2020Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA number of serious human adenovirus (HAdV) outbreaks have been recently reported: HAdV-B7 (Israel, Singapore, and USA), HAdV-B7d (USA and China), HAdV-D8, -D54, and -C2 (Japan), HAdV-B14p1 (USA, Europe, and China), and HAdV-B55 (China, Singapore, and France).
methodsTo understand the epidemiology of HAdV infections in Singapore, we studied 533 HAdV-positive clinical samples collected from 396 pediatric and 137 adult patients in Singapore from 2012 to 2018. Genome sequencing and phylogenetic analyses were performed to identify HAdV genotypes, clonal clusters, and recombinant or novel HAdVs.
resultsThe most prevalent genotypes identified were HAdV-B3 (35.6%), HAdV-B7 (15.4%), and HAdV-E4 (15.2%). We detected 4 new HAdV-C strains and detected incursions with HAdV-B7 (odds ratio [OR], 14.6; 95% confidence interval [CI], 4.1-52.0) and HAdV-E4 (OR, 13.6; 95% CI, 3.9-46.7) among pediatric patients over time. In addition, immunocompromised patients (adjusted OR [aOR], 11.4; 95% CI, 3.8-34.8) and patients infected with HAdV-C2 (aOR, 8.5; 95% CI, 1.5-48.0), HAdV-B7 (aOR, 3.7; 95% CI, 1.2-10.9), or HAdV-E4 (aOR, 3.2; 95% CI, 1.1-8.9) were at increased risk for severe disease.
conclusionsSingapore would benefit from more frequent studies of clinical HAdV genotypes to identify patients at risk for severe disease and help guide the use of new antiviral therapies, such as brincidofovir, and potential administration of HAdV 4 and 7 vaccine.
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