Evidence map›Paper›PMID 31563879›Full record

ArticleGut2020

Zonulin in serum as a biomarker fails to identify the IBS, functional dyspepsia and non-coeliac wheat sensitivity.

Nicholas J Talley, Gerald J Holtmann, Michael Jones, Natasha A Koloski, Marjorie M Walker, Grace Burns, Michael D E Potter, Ayesha Shah, Simon Keely

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Gut, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. What is new in Rome V?: Redefining diagnostic criteria and clinical pathways in disorders of gut-brain interaction.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
  4. Article
  5. Review
  6. The road to Rome IV and beyond: Evolution, refinements and future considerations for the Rome criteria for functional gastrointestinal disorders.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
    Review
  7. Surrogate Markers of Intestinal Permeability, Bacterial Translocation and Gut-Vascular Barrier Damage Across Stages of Cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  8. Article
  9. Leaky Gut Syndrome: Myths and Management.Gastroenterology & hepatology · 2024
    Article
  10. Article
  11. Wheat-Related Disorders in Children: A 360-Degree View.Children (Basel, Switzerland) · 2024
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. [Duodenal Microbiome and Its Clinical Implications in Functional Dyspepsia].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022
    Review
  18. Review
  19. The Role of Leaky Gut in Functional Dyspepsia.Frontiers in neuroscience · 2022
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Nicholas J TalleyFaculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia Nicholas.Talley@newcastle.edu.au.ORCID 0000-0003-2537-3092
Gerald J HoltmannSchool of Medicine, The University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0002-0206-2358
Michael JonesDepartment of Psychology, Macquarie University, Ryde, New South Wales, Australia.
Natasha A KoloskiFaculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.ORCID 0000-0002-8647-5933
Marjorie M WalkerAnatomical Pathology, University of Newcastle, Newcastle, New South Wales, Australia.
Grace BurnsFaculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.
Michael D E PotterFaculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.ORCID 0000-0002-7330-6217
Ayesha ShahDepartment of Gastroenterology & Hepatology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
Simon KeelySchool of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia.ORCID 0000-0002-1248-9590
University of Newcastle Australia · AUThe University of Queensland · AUHunter Medical Research Institute · AUMacquarie University · AUPrincess Alexandra Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Celiac DiseaseDyspepsiaIrritable Bowel SyndromeWheat HypersensitivityBiomarkersHaptoglobinsHumansProtein PrecursorsBiomarkersHaptoglobinsProtein Precursorszonulinanxietybiomarkerscoeliac diseasefunctional dyspepsiairritable bowel syndrome

Identifiers

PMID31563879
OpenAlexW2977189985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.