Evidence map›Paper›PMID 31563673›Full record

ArticleNeuroscience letters2019

Mitoferrin-1 is required for brain energy metabolism and hippocampus-dependent memory.

Lisa Baldauf, Thomas Endres, Johannes Scholz, Elmar Kirches, Diane M Ward, Volkmar Lessmann, Katrin Borucki, Christian Mawrin

Open access · greenAbstract read
In one paragraph

Article in Neuroscience letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Mechanisms controlling cellular and systemic iron homeostasis.Nature reviews. Molecular cell biology · 2024
    Review
  4. Iron and Targeted Iron Therapy in Alzheimer's Disease.International journal of molecular sciences · 2023
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Lisa BaldaufInstitute of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany.
Thomas EndresInstitute of Physiology, Otto-von-Guericke University, Magdeburg, Germany.
Johannes ScholzInstitute of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany.
Elmar KirchesInstitute of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany.
Diane M WardDepartment of Pathology, School of Medicine, University of Utah, Utah, USA.
Volkmar LessmannInstitute of Physiology, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany.
Katrin BoruckiInstitute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University, Magdeburg, Germany.
Christian MawrinInstitute of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany. Electronic address: christian.mawrin@med.ovgu.de.
Otto-von-Guericke University Magdeburg · DECenter for Behavioral Brain Sciences · DEUniversity of Utah · US

Funding

The Genetic Analysis of Mitochondrial Iron MetabolismR01DK052380 · NIDDK · UNIVERSITY OF UTAH · PI WARD, DIANE MCVEY · 1998 to 2016
$5.6M
NIDDK NIH HHS R01 DK052380
6 · The paper itself

Abstract

Disturbed iron (Fe) ion homeostasis and mitochondrial dysfunction have been implicated in neurodegeneration. Both processes are related, because central Fe ion consuming biogenetic pathways take place in mitochondria and affect their oxidative energy metabolism. Iron is imported into mitochondria by the two homologous Fe ion importers mitoferrin-1 and mitoferrin-2. To elucidate more specifically the role of mitochondrial Fe ions for brain energy metabolism and for proper neuronal function, we generated mice with a neuron-specific knockout of mitoferrin-1 (Slc25a37

Indexed as

AnimalsBehavior, AnimalBrainEnergy MetabolismFemaleMaleMaze LearningMembrane Transport ProteinsMemoryMiceMice, KnockoutMitochondriaOxygen ConsumptionSpatial LearningMembrane Transport Proteinsmitoferrin protein, mouseBrainMitoferrin-1Mitoferrin-2

Identifiers

PMID31563673
PMCPMC7254743
OpenAlexW2975625807

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.