ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Sex Differences in the Amygdala Resting-State Connectome of Children With Autism Spectrum Disorder.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Sex/gender differences in the human autistic brains: A systematic review of 20 years of neuroimaging research.NeuroImage. Clinical · 2021Pooled it
- Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings.NeuroImage. Clinical · 2021Pooled it
- Aberrant multivariate mapping between behavioral profiles and cortical morphological brain networks in children with autism spectrum disorder.Translational psychiatry · 2026Article
- Neonatal amygdala microstructure and structural connectivity are associated with autistic traits at 2 years of age.Developmental cognitive neuroscience · 2026Article
- Sex Differences in Spatiotemporal Consistency and Effective Connectivity of the Precuneus in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Sex Similarities and Differences in Brain Dynamic Functional Connectivity Among Individuals With and Without Autism Spectrum Disorders.Human brain mapping · 2025Article
- Functional Connectivity in the Social Perception Pathway at Birth Is Linked to Attention to Faces at Four Months.Biological psychiatry global open science · 2025Article
- Age-related differences in axon pruning and myelination may alter neural signaling in autism spectrum disorder.Molecular autism · 2025Article
- Sex Differences in Functional Gradients and Dynamic Functional Connectivity in Preschool-Aged Children With ASD.CNS neuroscience & therapeutics · 2025Article
- Sex Differences in the Striatal Contributions to Longitudinal Fine Motor Development in Autistic Children.Biological psychiatry · 2025Article
- Sex-specific DNA methylation signatures of autism spectrum disorder from whole genome bisulfite sequencing of newborn blood.Biology of sex differences · 2025Article
- Sex-specific cerebrovascular reactivity differences in autistic children related to functional connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Sex differences in trajectories of cortical development in autistic children from 2-13 years of age.Molecular psychiatry · 2024Article
- Sex differences in the flexibility of dynamic network reconfiguration of autism spectrum disorder based on multilayer network.Brain imaging and behavior · 2024Article
- Eigenvector Centrality Characterization on fMRI Data: Gender and Node Differences in Normal and ASD Subjects : Author name.Journal of autism and developmental disorders · 2024Article
- Atypical functional connectivity between the amygdala and visual, salience regions in infants with genetic liability for autism.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Why do we need sex-balanced studies of autism?Autism research : official journal of the International Society for Autism Research · 2023Article
- Insights into Sex and Gender Differences in Brain and Psychopathologies Using Big Data.Life (Basel, Switzerland) · 2023Review
- Volumetric Analysis of Amygdala and Hippocampal Subfields for Infants with Autism.Journal of autism and developmental disorders · 2023Article
- Sex and gender in neurodevelopmental conditions.Nature reviews. Neurology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMultifactorial liability models predict greater dissimilarity in the neural phenotype of autism spectrum disorder (ASD) in female individuals than in male individuals, while gender incoherence and extreme male brain models predict attenuated sex differences in ASD. The amygdala is an informative target to explore these models because it is implicated in both the neurobiology of ASD and sex differences in typical development.
methodsThis study investigated amygdala resting-state functional connectivity in a cohort of 116 children with ASD (36 female) and 58 typically developing children (27 female) 2 to 7 years of age during natural sleep. First, multivariate distance matrix regression assessed global sex and diagnostic differences across the amygdala connectome. Second, univariate general linear models identified regions with mean connectivity differences.
resultsMultivariate distance matrix regression revealed greater differences between typically developing children and those with ASD in females than in males, consistent with multifactorial liability models, and attenuated sex differences in the left amygdala connectome of children with ASD in a pattern consistent with the gender incoherence model. Univariate analysis identified similar sex differences in dorsomedial and ventral prefrontal cortices, lingual gyrus, and posterior cingulate cortex, but also noted that lower amygdala connectivity with superior temporal sulcus is observed across sexes.
conclusionsThis study provides evidence that compared with sex-matched control subjects, ASD manifests differently in the brain at the time of diagnosis and prior to the influence of compensatory mechanisms in male and female children, consistent with multifactorial liability models, and that ASD is associated with reduced sex differences in a pattern consistent with gender incoherence models.
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