ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2019
Global Left Ventricular Strain at Presentation Is Associated with Subsequent Recovery in Patients with Peripartum Cardiomyopathy.
Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Hemodynamic Patterns and Left Ventricular Function Recovery in Peripartum Cardiomyopathy: A Comprehensive Echocardiographic Analysis.JACC. Asia · 2025Article
- Hypertensive Disorders of Pregnancy and Peripartum Cardiomyopathy: A Meta-Analysis of Prevalence and Impact on Left Ventricular Function and Mortality.Journal of clinical medicine · 2025Review
- Peripartum cardiomyopathy: a comprehensive and contemporary review.Heart failure reviews · 2024Review
- Diagnosis and management of peripartum cardiomyopathy and recurrence risk.International journal of cardiology. Congenital heart disease · 2024Article
- Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human.Science translational medicine · 2024Article
- Biomarkers in Peripartum Cardiomyopathy-What We Know and What Is Still to Be Found.Biomolecules · 2024Review
- Transthoracic Echocardiographic Assessment of the Heart in Pregnancy-a position statement on behalf of the British Society of Echocardiography and the United Kingdom Maternal Cardiology Society.Echo research and practice · 2023Review
- Meeting the Challenges of Myocarditis: New Opportunities for Prevention, Detection, and Intervention-A Report from the 2021 National Heart, Lung, and Blood Institute Workshop.Journal of clinical medicine · 2022Article
- Using Echocardiography and Biomarkers to Determine Prognosis in Peripartum Cardiomyopathy: A Systematic Review.Cureus · 2022Review
- Assessing the future risks of subsequent pregnancies in peripartum cardiomyopathy.Heart failure reviews · 2022Review
- The roles of global longitudinal strain imaging in contemporary clinical cardiology.Journal of medical ultrasonics (2001) · 2022Review
- Peripartum Cardiomyopathy: Diagnostic and Prognostic Value of Cardiac Magnetic Resonance in the Acute Stage.Diagnostics (Basel, Switzerland) · 2022Article
- Dyspnea in pregnancy might be related to the incomplete physiological adaptation of the heart.Journal of cardiovascular and thoracic research · 2022Article
- Perioperative management of emergent cesarean section in a patient with peripartum cardiomyopathy and orthopnea: a case report.The Journal of international medical research · 2021Article
- Cardiac Function in Women With Peripartum Cardiomyopathy: The Tip of the Iceberg.JACC. Case reports · 2021Article
- Peripartum cardiomyopathy in Iraq: initial registry-based data and 6 month outcomes.ESC heart failure · 2021Article
- Cardiovascular Magnetic Resonance in Peripartum Cardiomyopathy: Comparison with Idiopathic Dilated Cardiomyopathy.Diagnostics (Basel, Switzerland) · 2021Article
- Echocardiography for the Pregnant Heart.Current treatment options in cardiovascular medicine · 2021Review
- The strain and strain rate imaging paradox in echocardiography: overabundant literature in the last two decades but still uncertain clinical utility in an individual case.Archives of medical sciences. Atherosclerotic diseases · 2020Article
- Impact of Simultaneous Consideration of Cardiac and Vascular Function on Long-Term All-Cause and Cardiovascular Mortality.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundPeripartum cardiomyopathy (PPCM) is a serious complication of pregnancy associated with variable degrees of left ventricular (LV) recovery. The aim of this study was to test the hypothesis that global LV strain at presentation has prognostic value in patients with PPCM.
methodsOne hundred patients with PPCM aged 30 ± 6 years were enrolled in the multicenter Investigation in Pregnancy Associated Cardiomyopathy study along with 21 normal female control subjects. Speckle-tracking global longitudinal strain (GLS) and global circumferential strain (GCS) analysis was performed. The predefined primary combined outcome variable was death, transplantation, LV assist device implantation, or evidence of persistent LV dysfunction (LV ejection fraction [LVEF] < 50%) at 1 year.
resultsGLS measurement was feasible in 110 subjects: 89 of 90 patients with PPCM (99%) with echocardiographic data and all 21 control subjects. Of 84 patients (94%) with 1-year follow-up, 21 (25%) had unfavorable primary outcomes: four LV assist device placements, two deaths, and 15 patients with persistent LV dysfunction. GLS at presentation with a cutoff of 10.6% (absolute value) was specifically associated with the subsequent primary outcome with 75% sensitivity and 95% specificity. GCS at presentation with a cutoff of 10.1% was associated with the primary outcome with 78% sensitivity and 84% specificity. GLS and GCS remained significantly associated with outcomes after adjusting for LVEF (GLS odds ratio, 2.07; P < .001; GCS odds ratio, 1.37; P = .005). GLS was significantly additive to LVEF (C statistic = 0.76-0.91, net reclassification improvement = 1.32, P < .001).
conclusionsGLS and GCS in patients with PPCM at presentation were associated with subsequent clinical outcomes, including death, LV assist device implantation, and evidence of persistent LV dysfunction. Strain measures may add prognostic information over LVEF for risk stratification.
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