Evidence map›Paper›PMID 31563295›Full record

ArticleAnnals of epidemiology2019

Smoking history, intensity, and duration and risk of prostate cancer recurrence among men with prostate cancer who received definitive treatment.

Saira Khan, Shivani Thakkar, Bettina Drake

Abstract read
In one paragraph

Article in Annals of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Saira KhanEpidemiology program, College of Health Sciences, University of Delaware, Newark, DE. Electronic address: khans@udel.edu.
Shivani ThakkarDivision of Public Health Sciences, Department of Surgery, Washington University in St. Louis School of Medicine, St. Louis, MO.
Bettina DrakeDivision of Public Health Sciences, Department of Surgery, Washington University in St. Louis School of Medicine, St. Louis, MO.
Washington University in St. Louis · USUniversity of Delaware · US

Funding

Training ProgramU54CA153460 · NCI · WASHINGTON UNIVERSITY · PI COLDITZ, GRAHAM A. · 2010 to 2015
$5.3M
Postdoctoral Training in Cancer Prevention and ControlT32CA190194 · NCI · WASHINGTON UNIVERSITY · PI GRAHAM A. COLDITZ, AIMEE S JAMES · 2014 to 2026
$4.7M
NCI NIH HHS T32 CA190194NCI NIH HHS U54 CA153460
6 · The paper itself

Abstract

purposeTo examine the association of smoking history and multiple measures of smoking intensity and duration with risk of biochemical recurrence in men treated for prostate cancer.

methodsWe conducted a prospective cohort study of 1641 men (773 ever-smokers) treated with radical prostatectomy or radiation between 2003 and 2010. The association between ever-smoking and risk of biochemical recurrence was examined using Cox Proportional Hazards models with adjustment for confounders. Among ever-smokers, we further assessed the association between multiple measures of smoking duration and intensity and risk of biochemical recurrence.

resultsIn the full cohort, we observed no association between ever-smoking and risk of biochemical recurrence. However, among ever-smokers, a smoking duration of greater than or equal to 10 years was significantly associated with biochemical recurrence (hazard ratio: 2.32, 95% confidence interval: 1.01, 5.33). Our results also suggested that greater than or equal to 10 pack-years of smoking may be associated with an increased risk of biochemical recurrence (hazard ratio: 1.75, 95% confidence interval: 0.97, 3.15). No association was observed between packs smoked per day or years since smoking cessation (among former smokers) and risk of biochemical recurrence.

conclusionSmoking duration is a significant predicator of biochemical recurrence among men with prostate cancer who are current or former smokers.

Indexed as

AdultBiomarkers, TumorCohort StudiesHumansMaleMiddle AgedNeoplasm Recurrence, LocalProportional Hazards ModelsProspective StudiesProstatectomyProstate-Specific AntigenProstatic NeoplasmsRisk FactorsSmokingSmoking CessationTime FactorsBiomarkers, TumorProstate-Specific AntigenBiochemical recurrencePacks per dayPack-yearsProstate cancerSmokingSmoking cessationSmoking duration

Identifiers

PMID31563295
PMCPMC6914316
OpenAlexW2972175419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.