Evidence map›Paper›PMID 31562886›Full record

ArticleBrain, behavior, and immunity2020

Association of inflammatory markers with hearing impairment: The English Longitudinal Study of Ageing.

Camille Lassale, Pierluigi Vullo, Dorina Cadar, G David Batty, Andrew Steptoe, Paola Zaninotto

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 45 citations in OpenAlex.

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  15. Allostatic load and risk of hearing impairment.Brain, behavior, & immunity - health · 2022
    Article
  16. Subjective Aging and Objectively Assessed Hearing Function: A Prospective Study of Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022
    Article
  17. Review
  18. The Link between Gut Dysbiosis Caused by a High-Fat Diet and Hearing Loss.International journal of molecular sciences · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Camille LassaleDepartment of Epidemiology and Public Health, University College London, London, UK; Department of Behavioural Science and Health, University College London, London, UK; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain. Electronic address: classale@imim.es.
Pierluigi VulloDepartment of Epidemiology and Public Health, University College London, London, UK.
Dorina CadarDepartment of Behavioural Science and Health, University College London, London, UK.
G David BattyDepartment of Epidemiology and Public Health, University College London, London, UK; School of Biological & Population Health Sciences, Oregon State University, USA.
Andrew SteptoeDepartment of Behavioural Science and Health, University College London, London, UK.
Paola ZaninottoDepartment of Epidemiology and Public Health, University College London, London, UK.
University College London · GBOregon State University · US

Funding

Project-001R01AG017644 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI Andrew Steptoe · 2000 to 2026
$56.2M
NIA NIH HHS R01 AG017644
6 · The paper itself

Abstract

backgroundHearing impairment is common at an older age and has considerable social, health and economic implications. With an increase in the ageing population, there is a need to identify modifiable risk factors for hearing impairment. A shared aetiology with cardiovascular disease (CVD) has been advanced as CVD risk factors (e.g. obesity, type 2 diabetes) are associated with a greater risk of hearing impairment. Moreover, low-grade inflammation is implicated in the aetiology of CVD. Accordingly, our aim was to investigate the association between several markers of inflammation - C-reactive protein, fibrinogen and white blood cell count - and hearing impairment.

methodsParticipants of the English Longitudinal Study of Ageing aged 50-93 were included. Inflammatory marker data from both wave 4 (baseline, 2008/09) and wave 6 (2012/13) were averaged to measure systemic inflammation. Hearing acuity was measured with a simple handheld tone-producing device at follow-up (2014/15).

resultsAmong 4879 participants with a median age of 63 years at baseline, 1878 (38.4%) people presented hearing impairment at follow-up. All three biomarkers were positively and linearly associated with hearing impairment independent of age and sex. After further adjustment for covariates, including cardiovascular risk factors (smoking, physical activity, obesity, diabetes, hypertension, cholesterol), memory and depression, only the association with white blood cell count remained significant: odds ratio per log-unit increase; 95% confidence interval = 1.46; 1.11, 1.93.

conclusionsWhile white blood cell count was positively associated with hearing impairment in older adults, no relationships were found for two other markers of low-grade inflammation.

Indexed as

AgedAged, 80 and overAgingBiomarkersC-Reactive ProteinFemaleFibrinogenHearing LossHumansLeukocyte CountLongitudinal StudiesMaleMiddle AgedRisk FactorsBiomarkersC-Reactive ProteinFibrinogenAgeingC-reactive proteinFibrinogenHearing impairmentInflammationLeukocyte count

Identifiers

PMID31562886
PMCPMC6906240
OpenAlexW2976708507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.