ArticleNeuropharmacology2019
Pharmacological mechanisms of alcohol analgesic-like properties in mouse models of acute and chronic pain.
Article in Neuropharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 59 citations in OpenAlex.
- Pain as a causal motivator of alcohol consumption: Associations with gender and race.Journal of psychopathology and clinical science · 2023Trial
- Aromatase inhibitors induce pain-like musculoskeletal symptoms in mice: behavioural, pharmacological and pathophysiological characterization.British journal of pharmacology · 2026Article
- Article
- A conceptual framework for the intersection of hyperalgesia and hyperkatifeia in alcohol addiction.Alcohol (Fayetteville, N.Y.) · 2025Review
- Chronic alcohol drinking delays recovery from capsaicin- and nerve injury-induced hypersensitivity in mice.Alcohol (Fayetteville, N.Y.) · 2025Article
- Chronic pain increases sensitivity to pain-induced reinstatement of ethanol seeking in male mice.Alcohol (Fayetteville, N.Y.) · 2025Article
- Persistent inflammation does not promote aversion-resistant binge-like alcohol drinking in rats.Alcohol (Fayetteville, N.Y.) · 2025Article
- Chronic alcohol drinking delays recovery from capsaicin- and nerve injury-induced hypersensitivity in mice.bioRxiv : the preprint server for biology · 2025Article
- Intersection of alcohol use, pain symptoms, and negative affect in total knee arthroplasty patients and people with HIV.The journal of pain · 2025Article
- Alcohol and cannabis use for pain management: Translational findings of relative risks, benefits, and interactions.Physiology & behavior · 2025Review
- Article
- Identification of ethanol analgesia quantitative trait loci and candidate genes in BXD recombinant inbred mouse lines.Addiction biology · 2025Article
- The Dopamine System in Mediating Alcohol Effects in Humans.Current topics in behavioral neurosciences · 2025Review
- A neural circuit for alcohol withdrawal-induced hyperalgesia in a nondependent state.Science advances · 2024Article
- Determinants of perceived pain relief from acute alcohol intake in a laboratory setting.Drug and alcohol dependence reports · 2024Article
- Identification of ethanol analgesia quantitative trait loci and candidate genes in BXD recombinant inbred mouse lines.bioRxiv : the preprint server for biology · 2024Article
- Within and Beyond the Binary: Sex and Gender Differences in Pain and Alcohol Use Disorder.Current addiction reports · 2024Article
- Alcohol use and the pain system.Advances in drug and alcohol research · 2024Review
- Neural and Psychosocial Mechanisms Underlying Alcohol Use and Pain Interactions: Overview of Current Evidence and Future Directions.Current addiction reports · 2023Article
- Electroencephalography-Based Effects of Acute Alcohol Intake on the Pain Matrix.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Alcohol use and chronic pain are highly comorbid. Acute alcohol use typically produces an analgesic effect. However, chronic use can worsen the progression of chronic pain. In rodent models, acute models of pain have primarily been used to investigate the relationship between alcohol and pain analgesia. Here, we use two models of chronic pain, chronic inflammatory and peripheral neuropathic pain, to investigate acute alcohol's antinociceptive and analgesic properties. We hypothesize that acute ethanol is acting through opioid receptors to create an analgesic-like effect in both reflexive and affective dimensions of pain. Using male and female C57BL/6J mice, oral ethanol administration (0-1.25 g/kg) showed a dose-dependent reversal of mechanical hypersensitivity in both Complete Freund's Adjuvant (CFA) and chronic constriction injury (CCI) models of chronic inflammatory and neuropathic pain. No sex differences were observed. Using the conditioned place preference (CPP) task to assess the subjective responses to ethanol's anti-nociceptive properties, CCI-injured animals showed a preference for the ethanol-paired side, suggesting a reduction in an aversive and pain-like state produced by nerve injury. These effects are likely mediated through the kappa and possibly the mu opioid systems, since ethanol-induced anti-nociception following CCI was fully reversed by pretreatment with the kappa selective antagonist, nor-BNI, or high doses of naltrexone. These data show that ethanol possesses analgesic-like properties in chronic inflammatory and neuropathic pain models in mice and provide new insight into ethanol as it relates to chronic pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.