Evidence map›Paper›PMID 31562627›Full record

ArticleAdvances in experimental medicine and biology2019

Contributions of 12/15-Lipoxygenase to Bleeding in the Brain Following Ischemic Stroke.

Yi Zheng, Yu Liu, Hulya Karatas, Kazim Yigitkanli, Theodore R Holman, Klaus van Leyen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Yi ZhengNeuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Yu LiuZhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People's Hospital of Jinan University, Zhuhai, Guangdong, China.
Hulya KaratasInstitute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.
Kazim YigitkanliMedicana Bursa Hospital, Neurosurgery Clinic, Bursa, Turkey.
Theodore R HolmanDepartment of Chemistry and Biochemistry, University of California at Santa Cruz, Santa Cruz, CA, USA.
Klaus van LeyenNeuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. klaus_vanleyen@hms.harvard.edu.
Massachusetts General Hospital · USBursa Technical University · TRHacettepe University · TRUniversity of California, Santa Cruz · USZhuhai People's Hospital · CN

Funding

12-Lipoxygenase and Ischemic Brain Cell DeathR01NS049430 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VAN LEYEN, KLAUS · 2005 to 2015
$3.6M
Development of human 12/15-lipoxygenase therapeutics for strokeUH3NS106854 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VAN LEYEN, KLAUS · 2019 to 2020
$1.3M
Novel 12/15 lipoxygenase inhibitors for the treatment of strokeR21NS087165 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VAN LEYEN, KLAUS · 2014 to 2015
$576k
Development of human 12/15-lipoxygenase therapeutics for strokeUG3NS106854 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VAN LEYEN, KLAUS · 2018 to 2018
$498k
NINDS NIH HHS R01 NS049430NINDS NIH HHS R21 NS087165NINDS NIH HHS UG3 NS106854NINDS NIH HHS UH3 NS106854
6 · The paper itself

Abstract

Ischemic strokes are caused by one or more blood clots that typically obstruct one of the major arteries in the brain, but frequently also result in leakage of the blood-brain barrier and subsequent hemorrhage. While it has long been known that the enzyme 12/15-lipoxygenase (12/15-LOX) is up-regulated following ischemic strokes and contributes to neuronal cell death, recent research has shown an additional major role for 12/15-LOX in causing this hemorrhagic transformation. These findings have important implications for the use of 12/15-LOX inhibitors in the treatment of stroke.

Indexed as

Arachidonate 15-LipoxygenaseBrain IschemiaHemorrhageStrokeBlood-Brain BarrierBrainHumansArachidonate 15-Lipoxygenase12-HETE15-HETEBlood-brain barrierEicosanoidHemorrhageHemorrhagic transformationIschemiaIschemic strokeLipoxygenaseNeuroprotectionSTAT6Tissue plasminogen activatortPAWarfarin

Identifiers

PMID31562627
PMCPMC7278041
OpenAlexW2976420729

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.