ArticleAnnals of surgical oncology2020
Preoperative Delays in the Treatment of DCIS and the Associated Incidence of Invasive Breast Cancer.
Article in Annals of surgical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of Surgical Delay on Breast Cancer Prognosis: Systematic Review and Meta-analysis.Annals of surgical oncology · 2026Pooled it
- Breast imaging and cancer diagnosis during the COVID-19 pandemic: recommendations from the Italian College of Breast Radiologists by SIRM.La Radiologia medica · 2020Guideline
- The Significance of C-Reactive Protein Value and Tumor Grading for Malignant Tumors: A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- The impact of nurse navigation on timeliness to treatment for benign high-risk breast pathology.Breast cancer research and treatment · 2023Article
- Benefits versus drawbacks of delaying surgery due to additional consultations in older patients with breast cancer.Cancer reports (Hoboken, N.J.) · 2023Article
- Utilization of a rapid diagnostic centre during the COVID-19 pandemic reduced diagnostic delays in breast cancer.American journal of surgery · 2023Article
- MiRNA expression deregulation correlates with the Oncotype DXBreast cancer research : BCR · 2022Article
- Neoadjuvant Endocrine Therapy and Delays in Surgery for Ductal Carcinoma in Situ: Implications for the Coronavirus Pandemic.Annals of surgical oncology · 2022Article
- ASO Author Reflections: Neoadjuvant Endocrine Therapy: A Pill in Time Saves Nine.Annals of surgical oncology · 2022Article
- Unresected screen-detected ductal carcinoma in situ: Outcomes of 311 women in the Forget-Me-Not 2 study.Breast (Edinburgh, Scotland) · 2022Article
- Prolonged Time from Diagnosis to Breast-Conserving Surgery is Associated with Upstaging in Hormone Receptor-Positive Invasive Ductal Breast Carcinoma.Annals of surgical oncology · 2021Article
- Patient and Caregiver Considerations and Priorities When Selecting Hospitals for Complex Cancer Care.Annals of surgical oncology · 2021Article
- Severe Impact of Covid-19 Pandemic on Breast Cancer Care in Italy: A Senonetwork National Survey.Clinical breast cancer · 2021Article
- Impact of the COVID-19 pandemic on diagnosis, stage, and initial treatment of breast cancer in the Netherlands: a population-based study.Journal of hematology & oncology · 2021Article
- Delayed Breast Cancer Detection in an Asian Country (Taiwan) with Low COVID-19 Incidence.Cancer management and research · 2021Article
- Association Between Time to Operation and Pathologic Stage in Ductal Carcinoma in Situ and Early-Stage Hormone Receptor-Positive Breast Cancer.Journal of the American College of Surgeons · 2020Article
- A system for risk stratification and prioritization of breast cancer surgeries delayed by the COVID-19 pandemic: preparing for re-entry.Breast cancer research and treatment · 2020Review
- Breast cancer care during a pandemic: an opportune time for cryoablation?Breast cancer research and treatment · 2020Article
- Recommendations for prioritization, treatment, and triage of breast cancer patients during the COVID-19 pandemic. the COVID-19 pandemic breast cancer consortium.Breast cancer research and treatment · 2020Article
- Treatment of Ductal Carcinoma in Situ: Considerations for Tailoring Therapy in the Contemporary Era.Current breast cancer reports · 2020Article
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Abstract
backgroundAlthough treatment delays have been associated with survival impairment for invasive breast cancer, this has not been thoroughly investigated for ductal carcinoma in situ (DCIS). With trials underway to assess whether DCIS can remain unresected, this study was performed to determine whether longer times to surgery are associated with survival impairment or increased invasion.
methodsA population-based study of prospectively collected national data derived from women with a clinical diagnosis of DCIS between 2004 and 2014 was conducted using the National Cancer Database. Overall survival (OS) and presence of invasion were assessed as functions of time by evaluating five intervals (≤ 30, 31-60, 61-90, 91-120, 121-365 days) between diagnosis and surgery. Subset analyses assessed those having pathologic DCIS versus invasive cancer on final pathology.
resultsAmong 140,615 clinical DCIS patients, 123,947 had pathologic diagnosis of DCIS and 16,668 had invasive ductal carcinoma. For all patients, 5-year OS was 95.8% and unadjusted median delay from diagnosis to surgery was 38 days. With each delay interval increase, added relative risk of death was 7.4% (HR 1.07; 95% CI 1.05-1.10; P < 0.001). On final pathology, 5-year OS for noninvasive patients was 96.0% (95% CI 95.9-96.1%) versus 94.9% (95% CI 94.6-95.3%) for invasive patients. Increasing delay to surgery was an independent predictor of invasion (OR 1.13; 95% CI 1.11-1.15; P < 0.001).
conclusionsDespite excellent OS for invasive and noninvasive cohorts, invasion was seen more frequently as delay increased. This suggests that DCIS trials evaluating nonoperative management, which represents infinite delay, require long term follow up to ensure outcomes are not compromised.
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