Evidence map›Paper›PMID 31562556›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2019

Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder.

Thiago Wendt Viola, Jaqueline Bohrer Schuch, Diego Luiz Rovaris, Rafael Genovese, Lucca Tondo, Breno Sanvicente-Vieira, Aline Zaparte, Renata Basso Cupertino, Bruna Santos da Silva, Claiton Henrique Dotto Bau and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Thiago Wendt ViolaDevelopmental Cognitive Neuroscience Lab, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Avenida Ipiranga 6691 - Predio 11, sala 926, Jardim Botânico, Porto Alegre, RS, Brazil.
Jaqueline Bohrer SchuchCenter for Drug and Alcohol Research, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Diego Luiz RovarisDepartment of Psychiatry, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Rafael GenoveseDevelopmental Cognitive Neuroscience Lab, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Avenida Ipiranga 6691 - Predio 11, sala 926, Jardim Botânico, Porto Alegre, RS, Brazil.
Lucca TondoDevelopmental Cognitive Neuroscience Lab, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Avenida Ipiranga 6691 - Predio 11, sala 926, Jardim Botânico, Porto Alegre, RS, Brazil.
Breno Sanvicente-VieiraDepartment of Psychology, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, Brazil.
Aline ZaparteDevelopmental Cognitive Neuroscience Lab, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Avenida Ipiranga 6691 - Predio 11, sala 926, Jardim Botânico, Porto Alegre, RS, Brazil.
Renata Basso CupertinoADHD Outpatient Program, Adult Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Bruna Santos da SilvaADHD Outpatient Program, Adult Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Claiton Henrique Dotto BauADHD Outpatient Program, Adult Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Rodrigo Grassi-OliveiraDevelopmental Cognitive Neuroscience Lab, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Avenida Ipiranga 6691 - Predio 11, sala 926, Jardim Botânico, Porto Alegre, RS, Brazil. rodrigo.grassi@pucrs.br.ORCID 0000-0001-9911-5921
Pontifícia Universidade Católica do Rio Grande do Sul · BRUniversidade Federal do Rio Grande do Sul · BRPontifícia Universidade Católica do Rio de Janeiro · BR

Funding

Gene-environment interactions in COCCaINE Use Disorder: Collaborative Case-Control Initiative in Coccaine AddictionR01DA044859 · NIDA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GRASSI-OLIVEIRA, RODRIGO, SCHMITZ, JOY MARIE · 2017 to 2021
$2.8M
NIDA NIH HHS R01 DA044859NIDA NIH HHS R01DA044859
6 · The paper itself

Abstract

The SNP rs2251214 of the SYT1 gene was recently associated with externalizing phenotypes, including ADHD and cocaine use disorder (CUD). Here, we investigated whether SYT1-rs2251214 could also be implicated with cognitive performance variations among women with CUD. Results showed that G homozygous (n = 146) have lower cognitive performance in the Stroop, Trail Making and Matrix Reasoning tests compared with A-allele carriers (n = 64), suggesting that rs2251214 may influence the severity of cognitive impairments in CUD.

Indexed as

AdultCase-Control StudiesCocaine-Related DisordersCognitive DysfunctionCross-Sectional StudiesFemaleHumansPolymorphism, Single NucleotideSynaptotagmin ISynaptotagmin ISYT1 protein, humanCocaine addictionCognitionSNARE complexStimulantsSubstance use disorders

Identifiers

PMID31562556
PMCPMC6858578
OpenAlexW2975295817

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.