Evidence map›Paper›PMID 31562550›Full record

ArticleJournal of cancer research and clinical oncology2019

Tumor-infiltrating lymphocytes and CD8

H Vihervuori, T A Autere, H Repo, S Kurki, L Kallio, M M Lintunen, K Talvinen, P Kronqvist

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Immune Microenvironment in Breast Cancer Metastasis.Advances in experimental medicine and biology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

H VihervuoriDepartment of Pathology, Institute of Biomedicine, University of Turku, Turku, Finland. himavi@utu.fi.ORCID http://orcid.org/0000-0002-6239-7184
T A AutereDepartment of Pathology, Institute of Biomedicine, University of Turku, Turku, Finland.
H RepoDepartment of Pathology, Institute of Biomedicine, University of Turku, Turku, Finland.
S KurkiAuria Biobank, Turku, Finland.
L KallioAuria Biobank, Turku, Finland.
M M LintunenDepartment of Pathology, Turku University Hospital, Turku, Finland.
K TalvinenDepartment of Pathology, Institute of Biomedicine, University of Turku, Turku, Finland.
P KronqvistDepartment of Pathology, Institute of Biomedicine, University of Turku, Turku, Finland.
University of Turku · FITurku Centre for Biotechnology · FITurku University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTumor inflammatory response was evaluated as a prognostic feature in triple-negative breast cancer (TNBC) and compared with the clinical prognosticators of breast cancer and selected biomarkers of cancer cell proliferation.

methodsTNBC patients (n = 179) with complete clinical data and up to 18-year follow-up were obtained from Auria biobank, Turku University Hospital, Turku, Finland. Tumor-infiltrating lymphocytes (TILs) and several subtypes of inflammatory cells detected with immunohistochemistry were evaluated in different tumor compartments in full tissue sections and tissue microarrays.

resultsDeficiency of stromal TILs and low number of CD8 DISCUSSION: TILs and CD8

Indexed as

AdultAgedAged, 80 and overCD8-Positive T-LymphocytesDisease-Free SurvivalFemaleHumansImmunohistochemistryLymphocytes, Tumor-InfiltratingMiddle AgedNeoadjuvant TherapyPrognosisTriple Negative Breast NeoplasmsCD8InflammationPrognosisProliferationTILTNBC

Identifiers

PMID31562550
PMCPMC6861359
OpenAlexW2977196766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.