ArticleThe ISME journal2020
Horizontal acquisition of a patchwork Calvin cycle by symbiotic and free-living Campylobacterota (formerly Epsilonproteobacteria).
Article in The ISME journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Phoronids and their tubes harbor distinct microbiomes compared to surrounding sediment.bioRxiv : the preprint server for biology · 2026Article
- Shifting microbial communities in acidified seawaters: insights from polychaetes living in the COIntegrative zoology · 2025Article
- Decoding microbial diversity, biogeochemical functions, and interaction potentials in red sea hydrothermal vents.Environmental microbiome · 2025Article
- Metagenomic binning reveals community and functional characteristics of sulfur- and methane-oxidizing bacteria in cold seep sponge ground.Environmental microbiome · 2025Article
- Metabolic redundancy and specialisation of novel sulfide-oxidizing Sulfurimonas and Sulfurovum along the brine-seawater interface of the Kebrit Deep.Environmental microbiome · 2025Article
- Microbial occurrence and symbiont detection in a global sample of lichen metagenomes.PLoS biology · 2024Article
- An intranuclear bacterial parasite of deep-sea mussels expresses apoptosis inhibitors acquired from its host.Nature microbiology · 2024Article
- Metabolic handoffs between multiple symbionts may benefit the deep-sea bathymodioline mussels.ISME communications · 2023Article
- Interactions among deep-sea mussels and their epibiotic and endosymbiotic chemoautotrophic bacteria: Insights from multi-omics analysis.Zoological research · 2023Article
- Environmental heterogeneity shapes the C and S cycling-associated microbial community in Haima's cold seeps.Frontiers in microbiology · 2023Article
- Global patterns of diversity and metabolism of microbial communities in deep-sea hydrothermal vent deposits.Microbiome · 2022Article
- The Gill Microbiota ofMicroorganisms · 2022Article
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- DNA Enrichment Methods for Microbial Symbionts in Marine Bivalves.Microorganisms · 2022Article
- Considerations for constructing a protein sequence database for metaproteomics.Computational and structural biotechnology journal · 2022Review
- Evaluation of RNAMicrobiology spectrum · 2021Article
- Comparative Metagenomics Reveals Microbial Communities and Their Associated Functions in Two Types of Fuzhuan Brick Tea.Frontiers in microbiology · 2021Article
- Hydrocarbon seepage in the deep seabed links subsurface and seafloor biospheres.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Spatial metabolomics of in situ host-microbe interactions at the micrometre scale.Nature microbiology · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most autotrophs use the Calvin-Benson-Bassham (CBB) cycle for carbon fixation. In contrast, all currently described autotrophs from the Campylobacterota (previously Epsilonproteobacteria) use the reductive tricarboxylic acid cycle (rTCA) instead. We discovered campylobacterotal epibionts ("Candidatus Thiobarba") of deep-sea mussels that have acquired a complete CBB cycle and may have lost most key genes of the rTCA cycle. Intriguingly, the phylogenies of campylobacterotal CBB cycle genes suggest they were acquired in multiple transfers from Gammaproteobacteria closely related to sulfur-oxidizing endosymbionts associated with the mussels, as well as from Betaproteobacteria. We hypothesize that "Ca. Thiobarba" switched from the rTCA cycle to a fully functional CBB cycle during its evolution, by acquiring genes from multiple sources, including co-occurring symbionts. We also found key CBB cycle genes in free-living Campylobacterota, suggesting that the CBB cycle may be more widespread in this phylum than previously known. Metatranscriptomics and metaproteomics confirmed high expression of CBB cycle genes in mussel-associated "Ca. Thiobarba". Direct stable isotope fingerprinting showed that "Ca. Thiobarba" has typical CBB signatures, suggesting that it uses this cycle for carbon fixation. Our discovery calls into question current assumptions about the distribution of carbon fixation pathways in microbial lineages, and the interpretation of stable isotope measurements in the environment.
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