Evidence map›Paper›PMID 31562371›Full record

ArticleScientific reports2019

A multi-source data integration approach reveals novel associations between metabolites and renal outcomes in the German Chronic Kidney Disease study.

Michael Altenbuchinger, Helena U Zacharias, Stefan Solbrig, Andreas Schäfer, Mustafa Büyüközkan, Ulla T Schultheiß, Fruzsina Kotsis, Anna Köttgen, Rainer Spang, Peter J Oefner and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Anomaly detection in mixed high-dimensional molecular data.Bioinformatics (Oxford, England) · 2023
    Article
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  14. Gaussian and Mixed Graphical Models as (multi-)omics data analysis tools.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Michael AltenbuchingerStatistical Bioinformatics, Institute of Functional Genomics, University of Regensburg, Am Biopark 9, 93053, Regensburg, Germany.
Helena U ZachariasInstitute of Computational Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
Stefan SolbrigDepartment of Physics, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.
Andreas SchäferDepartment of Physics, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.
Mustafa BüyüközkanInstitute of Computational Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
Ulla T SchultheißInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology, and Medical Bioinformatics, Faculty of Medicine and Medical Center, University of Freiburg, 79106, Freiburg, Germany.ORCID http://orcid.org/0000-0002-7541-5310
Fruzsina KotsisInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology, and Medical Bioinformatics, Faculty of Medicine and Medical Center, University of Freiburg, 79106, Freiburg, Germany.
Anna KöttgenInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology, and Medical Bioinformatics, Faculty of Medicine and Medical Center, University of Freiburg, 79106, Freiburg, Germany.ORCID http://orcid.org/0000-0002-4671-3714
Rainer SpangStatistical Bioinformatics, Institute of Functional Genomics, University of Regensburg, Am Biopark 9, 93053, Regensburg, Germany.
Peter J OefnerInstitute for Functional Genomics, University of Regensburg, Am Biopark 9, 93053, Regensburg, Germany.
Jan KrumsiekInstitute of Computational Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
Wolfram GronwaldInstitute for Functional Genomics, University of Regensburg, Am Biopark 9, 93053, Regensburg, Germany. Wolfram.Gronwald@klinik.uni-regensburg.de.
University of Regensburg · DEUniversity of Freiburg · DEHelmholtz Zentrum München · DECornell University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Omics data facilitate the gain of novel insights into the pathophysiology of diseases and, consequently, their diagnosis, treatment, and prevention. To this end, omics data are integrated with other data types, e.g., clinical, phenotypic, and demographic parameters of categorical or continuous nature. We exemplify this data integration issue for a chronic kidney disease (CKD) study, comprising complex clinical, demographic, and one-dimensional

Indexed as

MetabolomicsAlgorithmsBiomarkersFemaleGermanyHumansKidneyMagnetic Resonance SpectroscopyMaleModels, TheoreticalPrognosisRenal Insufficiency, ChronicBiomarkers

Identifiers

PMID31562371
PMCPMC6764972
OpenAlexW2975601106

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.