ArticleNature communications2019
12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population.
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In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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33citing papers in PubMed, 2 pooled it
7.0field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Pooled it
- Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects.Nature communications · 2023Pooled it
- Exploring Genetic Contributions to Prostate Cancer Risk in an Asian Population-Based Study.Cancer medicine · 2026Article
- Polygenic risk and germline genetics for prostate cancer in Asians: Where do we stand?Investigative and clinical urology · 2026Review
- Decoding ancestry-specific genetic risk: interpretable deep feature selection reveals prostate cancer SNP disparities in diverse populations.BioData mining · 2025Article
- Leveraging genome-wide association studies to better understand the etiology of cancers.Cancer science · 2025Review
- Association of genetic variants, protein domains, and phenotypes in the ZMIZ1 syndromic neurodevelopmental disorder.Frontiers in neuroscience · 2025Article
- ZMIZ1 Regulates Proliferation, Autophagy and Apoptosis of Colon Cancer Cells by Mediating Ubiquitin-Proteasome Degradation of SIRT1.Biochemical genetics · 2024Article
- An Inherited Allele Confers Prostate Cancer Progression and Drug Resistance via RFX6/HOXA10-Orchestrated TGFβ Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Treatment escalation and de-escalation of de-novo metastatic castration-sensitive prostate cancer.Nagoya journal of medical science · 2024Review
- A west African ancestry-associated SNP on 8q24 predicts a positive biopsy in African American men with suspected prostate cancer following PSA screening.The Prostate · 2024Article
- Zmiz1 is a novel regulator of brain development associated with autism and intellectual disability.Frontiers in psychiatry · 2024Article
- Inflammation in Prostate Cancer: Exploring the Promising Role of Phenolic Compounds as an Innovative Therapeutic Approach.Biomedicines · 2023Review
- Underlying Features of Prostate Cancer-Statistics, Risk Factors, and Emerging Methods for Its Diagnosis.Current oncology (Toronto, Ont.) · 2023Review
- Polygenic risk score for tumor aggressiveness and early-onset prostate cancer in Asians.Scientific reports · 2023Article
- ZMIZ proteins: partners in transcriptional regulation and risk factors for human disease.Journal of molecular medicine (Berlin, Germany) · 2022Review
- Prostate cancer risk in men of differing genetic ancestry and approaches to disease screening and management in these groups.British journal of cancer · 2022Review
- Combined analyses of RNA-sequence and Hi-C along with GWAS loci-A novel approach to dissect keloid disorder genetic mechanism.PLoS genetics · 2022Article
- Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure.BMC genomic data · 2022Article
- Clinical Utility of Germline Genetic Testing in Japanese Men Undergoing Prostate Biopsy.JNCI cancer spectrum · 2022Article
Corrections and comments
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Authors and funding
31 authors at 13 institutions in 3 countries.
Ryo TakataDepartment of Urology, Iwate Medical University, Morioka, 020-8505, Japan. rtakata@iwate-med.ac.jp.ORCID http://orcid.org/0000-0002-4860-8942
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.ORCID http://orcid.org/0000-0001-7099-8767
Masashi FujitaLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.ORCID http://orcid.org/0000-0002-1457-6233
Yukihide MomozawaLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Edward J SaundersThe Institute of Cancer Research, London, SW7 3RP, UK.
Hiroki YamadaDepartment of Urology, Jikei University School of Medicine, 105-8461, Tokyo, Japan.
Kazuhiro MaejimaLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Kaoru NakanoLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Yuichiro NishidaDepartment of Preventive Medicine, Faculty of Medicine, Saga University, 840-8502, Saga, Japan.ORCID http://orcid.org/0000-0003-2320-7234
Asahi HishidaDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, 464-8681, Nagoya, Japan.ORCID http://orcid.org/0000-0003-1761-6314
Kenji WakaiDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
Taiki YamajiDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, 104-0045, Japan.
Norie SawadaDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, 104-0045, Japan.ORCID http://orcid.org/0000-0002-9936-1476
Motoki IwasakiDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, 104-0045, Japan.
Shoichiro TsuganeCenter for Public Health Sciences, National Cancer Center, 104-0045, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4105-2774
Makoto SasakiIwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba, 028-3694, Japan.ORCID http://orcid.org/0000-0002-3108-4361
Atsushi ShimizuIwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba, 028-3694, Japan.ORCID http://orcid.org/0000-0001-8307-2461
Kozo TannoIwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba, 028-3694, Japan.
Naoko MinegishiTohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
Kichiya SuzukiTohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.ORCID http://orcid.org/0000-0001-5997-6567
Koichi MatsudaLaboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 108-8639, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7292-2686
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Johji InazawaDepartment of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 113-8510, Japan.
Shin EgawaDepartment of Urology, Jikei University School of Medicine, 105-8461, Tokyo, Japan.
Christopher A HaimanCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, 90033, USA.
Osamu OgawaDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, 606-8501, Japan.
Wataru ObaraDepartment of Urology, Iwate Medical University, Morioka, 020-8505, Japan.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.ORCID http://orcid.org/0000-0001-8748-5597
Shusuke AkamatsuLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. akamats@kuhp.kyoto-u.ac.jp.
Hidewaki NakagawaLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. hidewaki@riken.jp.
RIKEN Center for Integrative Medical Sciences · JPIwate Medical University · JPJikei University School of Medicine · JPKyoto University · JPNagoya University · JPTohoku University · JPAichi Cancer Center · JPInstitute of Cancer Research · GBNational Cerebral and Cardiovascular Center · JPSaga University · JPThe University of Tokyo · JPTokyo Medical and Dental University · JPUniversity of Southern California · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide association studies (GWAS) have identified ~170 genetic loci associated with prostate cancer (PCa) risk, but most of them were identified in European populations. We here performed a GWAS and replication study using a large Japanese cohort (9,906 cases and 83,943 male controls) to identify novel susceptibility loci associated with PCa risk. We found 12 novel loci for PCa including rs1125927 (TMEM17, P = 3.95 × 10
Indexed as
Genome-Wide Association StudyAgedAllelesGATA2 Transcription FactorGene FrequencyGenetic LociGenetic Predisposition to DiseaseGenotypeGenotyping TechniquesHumansIntracellular Signaling Peptides and ProteinsJapanMaleMembrane ProteinsMiddle AgedPolymorphism, Single NucleotideGATA2 protein, humanGATA2 Transcription FactorIntracellular Signaling Peptides and ProteinsMembrane ProteinsSUN2 protein, humanTMEM170A protein, humanTranscription FactorsZMIZ1 protein, human
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