ArticleNature communications2019
Structural puzzles in virology solved with an overarching icosahedral design principle.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed.
- Small viruses reveal bidirectional evolution between HK97-fold viruses and encapsulins via procapsids.Nature communications · 2026Article
- Article
- A geometric criterion links HIV-1 capsid topography to its biophysical properties and function.Nature communications · 2026Article
- Packaging of Single-Stranded RNA in Viruses and Virus-Like Particles.Annual review of biochemistry · 2026Review
- Many paths, similar destinations: viruses and bacterial microcompartments form polyhedra inside cells.Journal of virology · 2026Review
- Review
- Insights into the structural differences between homo- and heterodimers enriched from a cocktail of monoclonal antibodies against SARS-CoV-2.Scientific reports · 2026Article
- From disorder to icosahedral symmetry: How conformation-switching subunits enable RNA virus assembly.Science advances · 2025Article
- Exploring diverse supramolecular tessellation through hierarchical assemblies of nonalternant nanographene.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dynamic Assembly of Pentamer-Based Protein Nanotubes.ACS nano · 2025Article
- Solvation, geometry, and assembly of the tobacco mosaic virus.PNAS nexus · 2025Article
- General theory for packing icosahedral shells into multi-component aggregates.Nature communications · 2025Article
- The nucleocapsid architecture and structural atlas of the prototype baculovirus define the hallmarks of a new viral realm.Science advances · 2024Article
- Resolving viral structural complexity by super-resolution microscopy.Archives of virology · 2024Review
- Explicit description of viral capsid subunit shapes by unfolding dihedrons.Communications biology · 2024Article
- Exploring the Effects of Intersubunit Interface Mutations on Virus-Like Particle Structure and Stability.Biochemistry · 2024Article
- Studying Biomolecular Protein Complexes via Origami and 3D-Printed Models.International journal of molecular sciences · 2024Article
- Point mutation in a virus-like capsid drives symmetry reduction to form tetrahedral cages.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Limits of economy and fidelity for programmable assembly of size-controlled triply periodic polyhedra.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- pyCapsid: identifying dominant dynamics and quasi-rigid mechanical units in protein shells.Bioinformatics (Oxford, England) · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Viruses have evolved protein containers with a wide spectrum of icosahedral architectures to protect their genetic material. The geometric constraints defining these container designs, and their implications for viral evolution, are open problems in virology. The principle of quasi-equivalence is currently used to predict virus architecture, but improved imaging techniques have revealed increasing numbers of viral outliers. We show that this theory is a special case of an overarching design principle for icosahedral, as well as octahedral, architectures that can be formulated in terms of the Archimedean lattices and their duals. These surface structures encompass different blueprints for capsids with the same number of structural proteins, as well as for capsid architectures formed from a combination of minor and major capsid proteins, and are recurrent within viral lineages. They also apply to other icosahedral structures in nature, and offer alternative designs for man-made materials and nanocontainers in bionanotechnology.
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