Evidence map›Paper›PMID 31562315›Full record

ArticleNature communications2019

Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery.

Souvik Modi, Guillermo López-Doménech, Elise F Halff, Christian Covill-Cooke, Davor Ivankovic, Daniela Melandri, I Lorena Arancibia-Cárcamo, Jemima J Burden, Alan R Lowe, Josef T Kittler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 1 synthesis or guideline pooled it, 174 citations in OpenAlex.

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  19. Nanocatalytic Neuroprotection and Neurological Recovery Post-Traumatic Brain Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Souvik ModiNeuroscience, Physiology and Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK. souvikmodi@gmail.com.ORCID http://orcid.org/0000-0001-5474-7765
Guillermo López-DoménechNeuroscience, Physiology and Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK. g.lopez-domenech@ucl.ac.uk.ORCID http://orcid.org/0000-0002-3114-2082
Elise F HalffNeuroscience, Physiology and Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK.ORCID http://orcid.org/0000-0001-5814-0899
Christian Covill-CookeNeuroscience, Physiology and Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK.
Davor IvankovicNeuroscience, Physiology and Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK.ORCID http://orcid.org/0000-0002-4881-9096
Daniela MelandriNeuroscience, Physiology and Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK.ORCID http://orcid.org/0000-0002-3630-5143
I Lorena Arancibia-CárcamoNeuroscience, Physiology and Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK.ORCID http://orcid.org/0000-0002-0624-3850
Jemima J BurdenMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, WC1E 6BT, London, UK.ORCID http://orcid.org/0000-0001-5894-7043
Alan R LoweStructural & Molecular Biology, University College London, Gower Street, WC1E 6BT, London, UK.ORCID http://orcid.org/0000-0002-0558-3597
Josef T KittlerNeuroscience, Physiology and Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK. j.kittler@ucl.ac.uk.ORCID http://orcid.org/0000-0002-3437-9456
University College London · GBKing's College London · GBLondon Centre for Nanotechnology · GBMRC Laboratory for Molecular Cell Biology · GBTata Institute of Fundamental Research · IN

Funding

Medical Research Council MR/K015826/1
6 · The paper itself

Abstract

Mitochondrial Rho (Miro) GTPases localize to the outer mitochondrial membrane and are essential machinery for the regulated trafficking of mitochondria to defined subcellular locations. However, their sub-mitochondrial localization and relationship with other critical mitochondrial complexes remains poorly understood. Here, using super-resolution fluorescence microscopy, we report that Miro proteins form nanometer-sized clusters along the mitochondrial outer membrane in association with the Mitochondrial Contact Site and Cristae Organizing System (MICOS). Using knockout mouse embryonic fibroblasts we show that Miro1 and Miro2 are required for normal mitochondrial cristae architecture and Endoplasmic Reticulum-Mitochondria Contacts Sites (ERMCS). Further, we show that Miro couples MICOS to TRAK motor protein adaptors to ensure the concerted transport of the two mitochondrial membranes and the correct distribution of cristae on the mitochondrial membrane. The Miro nanoscale organization, association with MICOS complex and regulation of ERMCS reveal new levels of control of the Miro GTPases on mitochondrial functionality.

Indexed as

AnimalsBinding SitesBiological TransportCells, CulturedEmbryo, MammalianEndoplasmic ReticulumFibroblastsHeLa CellsHumansMice, KnockoutMicroscopy, ConfocalMicroscopy, Electron, TransmissionMitochondriaMitochondrial MembranesMitochondrial ProteinsProtein BindingMiro-1 protein, mouseMitochondrial Proteinsrho GTP-Binding ProteinsRhot2 protein, mouse

Identifiers

PMID31562315
PMCPMC6764964
OpenAlexW2975505461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.