ArticleNature communications2019
Soybean antiviral immunity conferred by dsRNase targets the viral replication complex.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- An antiviral jacalin-like lectin gene contributes to nonhost resistance and host determination of potexviruses among Brassicaceae.The New phytologist · 2026Article
- Systematic Screening of Host Interactors forPlants (Basel, Switzerland) · 2026Article
- The current state of Japanese soybean breeding using DNA marker technology.Breeding science · 2026Article
- Enhanced Soybean Immunity to the Soybean Mosaic Virus Through RNA Interference Targeting thePlants (Basel, Switzerland) · 2026Article
- South Korea is the center for the origin and emanation of soybean mosaic virus with Bayesian phylogeographic inference.Microbiology spectrum · 2025Article
- An RNase H-Like gene complements resistance to Bean common mosaic necrosis virus in Phaseolus vulgaris.The plant genome · 2025Article
- A tritrophic plant-insect-pathogen system used to develop a closely linked Rag2 and Rsv1-h recombinant haplotype in double-resistant soybean germplasm.BMC genomics · 2025Article
- Genome-Wide Association Study and Genomic Prediction of Soybean Mosaic Virus Resistance.International journal of molecular sciences · 2025Article
- A Bifunctional Nuclease Promotes the Infection of Zucchini Yellow Mosaic Virus in Watermelon by Targeting P3.Plants (Basel, Switzerland) · 2024Article
- Transgenic expression of artificial microRNA targeting soybean mosaic virus P1 gene confers virus resistance in plant.Transgenic research · 2024Article
- Identification of soybean mosaic virus strain SC7 resistance loci and candidate genes in soybean [Glycine max (L.) Merr.].Molecular genetics and genomics : MGG · 2024Article
- Analysis of Virus-Induced Double-Stranded RNA in Living Plant Cells by the dRBFC Assay.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Identification and functional validation of a new gene conferring resistance toFrontiers in plant science · 2024Article
- Manipulation of the Cellular Membrane-Cytoskeleton Network for RNA Virus Replication and Movement in Plants.Viruses · 2023Review
- Major viral diseases in grain legumes: designing disease resistant legumes from plant breeding and OMICS integration.Frontiers in plant science · 2023Review
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- Decades of Genetic Research onViruses · 2022Review
- Photosynthesis-related genes induce resistance against soybean mosaic virus: Evidence for involvement of the RNA silencing pathway.Molecular plant pathology · 2022Article
- A cluster of atypical resistance genes in soybean confers broad-spectrum antiviral activity.Plant physiology · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic positive-strand RNA viruses replicate their genomes in membranous compartments formed in a host cell, which sequesters the dsRNA replication intermediate from antiviral immune surveillance. Here, we find that soybean has developed a way to overcome this sequestration. We report the positional cloning of the broad-spectrum soybean mosaic virus resistance gene Rsv4, which encodes an RNase H family protein with dsRNA-degrading activity. An active-site mutant of Rsv4 is incapable of inhibiting virus multiplication and is associated with an active viral RNA polymerase complex in infected cells. These results suggest that Rsv4 enters the viral replication compartment and degrades viral dsRNA. Inspired by this model, we design three plant-gene-derived dsRNases that can inhibit the multiplication of the respective target viruses. These findings suggest a method for developing crops resistant to any target positive-strand RNA virus by fusion of endogenous host genes.
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