ArticleOccupational and environmental medicine2019
Functional, inflammatory and interstitial impairment due to artificial stone dust ultrafine particles exposure.
Article in Occupational and environmental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Biomonitoring of urban ultrafine particle exposure and associated health effects.International journal of public health · 2026Article
- The possible role of particulate matter on the respiratory microbiome: evidence from in vivo to clinical studies.Archives of toxicology · 2023Review
- Hazardous dusts from the fabrication of countertop: a review.Archives of environmental & occupational health · 2023Review
- The Triple Burden of Tuberculosis, Human Immunodeficiency Virus and Silicosis among Artisanal and Small-Scale Miners in Zimbabwe.International journal of environmental research and public health · 2022Article
- Rapid Assessment of Oxidative Damage Potential: A Comparative Study of Engineered Stone Dusts Using a Deoxyguanosine Assay.International journal of environmental research and public health · 2022Article
- COVID-19 Lockdown in Israel: The Environmental Effect on Ultrafine Particle Content in the Airway.International journal of environmental research and public health · 2022Observational
- Characterisation of dust emissions from machined engineered stones to understand the hazard for accelerated silicosis.Scientific reports · 2022Article
- Metal Ion Release from Engineered Stone Dust in Artificial Lysosomal Fluid-Variation with Time and Stone Type.International journal of environmental research and public health · 2021Article
- Pulmonary function parameters among marble industry workers in Lahore, Pakistan.F1000Research · 2021Article
- Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes.Particle and fibre toxicology · 2020Article
- Can the South African Milestones for Reducing Exposure to Respirable Crystalline Silica and Silicosis be Achieved and Reliably Monitored?Frontiers in public health · 2020Article
- European Respiratory Society International Congress 2018: four shades of epidemiology and tobacco control.ERJ open research · 2019Review
- Inflammatory biomarkers in workers exposed to silica dust: integrative review.Revista brasileira de medicina do trabalho : publicacao oficial da Associacao Nacional de Medicina do Trabalho-ANAMTReview
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveArtificial stone dust (ASD) contains high levels of ultrafine particles (UFP <1 µm) which penetrate deeply into the lungs. This study aimed to demonstrate the direct effect of UFP in the lungs of ASD-exposed workers on functional inflammatory and imaging parameters.
methods68 workers with up to 20 years of ASD exposure at the workplace were recruited from small enterprises throughout the country and compared with 48 non-exposed individuals. Pulmonary function test (PFT), CT, induced sputum (IS) and cytokine analyses were performed by conventional methods. The CT scans were evaluated for features indicative of silicosis in three zones of each lung. UFP were quantitated by the NanoSight LM20 system (NanoSight, Salisbury) using the Nanoparticle Tracking Analysis. Interleukin (IL)-6, IL-8 and tumour necrosis factor alpha (TNF-α) levels were measured by Luminex (R&D Systems).
resultsThirty-four patients had CT scores between 0 and 42, and 29 of them were diagnosed with silicosis. Content of the UFP retrieved from IS supernatants correlated negatively with the PFT results (total lung capacity r=-0.347, p=0.011; forced expiratory volume in 1 s r=-0.299, p=0.046; diffusion lung carbon monoxide in a single breath r=-0.425, p=0.004) and with the CT score (r=0.378, p=0.023), and with the inflammatory cytokines IL-8 (r=0.336, p=0.024), IL-6 (r=0.294, p=0.065) and TNF-α (r=0.409, p=0.007). Raw material of ASD was left to sedimentate in water for <15 min, and 50% of the floating particles were UFP. A cut-off of 8×10
conclusionsThis is the first demonstration of an association between UFP-related decreased PFT results, worsening of CT findings and elevation of inflammatory cytokines, which may be attributed to high-dose inhalation of UFP of ASD at the workplace.
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