Evidence map›Paper›PMID 31562223›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2020

TSPO Versus P2X7 as a Target for Neuroinflammation: An In Vitro and In Vivo Study.

Donatienne Van Weehaeghe, Evelien Van Schoor, Joke De Vocht, Michel Koole, Bala Attili, Sofie Celen, Lieven Declercq, Dietmar R Thal, Philip Van Damme, Guy Bormans and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 59 citations in OpenAlex.

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  5. Increased [Biomolecules · 2025
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  14. Review
  15. Quantification of the purinergic P2XJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Microglial TREM2 in amyotrophic lateral sclerosis.Developmental neurobiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Donatienne Van WeehaegheDivision of Nuclear Medicine, Department of Imaging and Pathology, University Hospitals Leuven, KU Leuven, Leuven, Belgium donatienne.vanweehaeghe@kuleuven.be.
Evelien Van SchoorDepartment of Neurology, University Hospitals Leuven, and Laboratory of Neurobiology, Center for Brain and Disease Research, VIB, KU Leuven, Leuven, Belgium.
Joke De VochtDepartment of Neurology, University Hospitals Leuven, and Laboratory of Neurobiology, Center for Brain and Disease Research, VIB, KU Leuven, Leuven, Belgium.
Michel KooleDivision of Nuclear Medicine, Department of Imaging and Pathology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
Bala AttiliLaboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium; and.
Sofie CelenLaboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium; and.
Lieven DeclercqLaboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium; and.
Dietmar R ThalLeuven Brain Institute, KU Leuven, Leuven, Belgium.
Philip Van DammeDepartment of Neurology, University Hospitals Leuven, and Laboratory of Neurobiology, Center for Brain and Disease Research, VIB, KU Leuven, Leuven, Belgium.
Guy BormansLaboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium; and.
Koen Van LaereDivision of Nuclear Medicine, Department of Imaging and Pathology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
KU Leuven · BEVIB-KU Leuven Center for Brain & Disease Research · BEUniversitair Ziekenhuis Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation is important in amyotrophic lateral sclerosis (ALS). The P2X7 receptor (P2X7R) is a promising target for neuroinflammation. The objective of this study was to compare

Indexed as

AdultAmyotrophic Lateral SclerosisFemaleFluorine RadioisotopesHumansIsotope LabelingMaleMiddle AgedPositron-Emission TomographyPyrazolesPyrimidinesReceptors, GABAReceptors, Purinergic P2X7Fluorine-18Fluorine RadioisotopesN,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)acetamidePyrazolesPyrimidinesReceptors, GABAReceptors, Purinergic P2X7TSPO protein, humanamyotrophic lateral sclerosisbrain specimenneuroinflammationP2X7translocator protein (TSPO)

Identifiers

PMID31562223
PMCPMC7198372
OpenAlexW2975242678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.