Evidence map›Paper›PMID 31562201›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2019

Newly Developed Dopamine D

Chloe J Jordan, Bree A Humburg, Eric B Thorndike, Anver Basha Shaik, Zheng-Xiong Xi, Michael H Baumann, Amy Hauck Newman, Charles W Schindler

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. ESG-1-60 and ESG-1-61: Novel dopamine DBritish journal of pharmacology · 2025
    Article
  3. Article
  4. The selective DNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Dopamine Receptor DThe Yale journal of biology and medicine · 2023
    Review
  10. Article
  11. A highly DNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Effects of the selective dopamine DBehavioural brain research · 2021
    Article
  17. Novel Dual-Target μ-Opioid Receptor and Dopamine DJournal of medicinal chemistry · 2021
    Article
  18. Article
  19. (±)VK4-40, a novel dopamine DBritish journal of pharmacology · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Chloe J JordanMolecular Targets and Medications Discovery Branch (C.J.J., B.A.H., A.B.S., Z.-X.X., A.H.N.), Designer Drug Research Unit (M.H.B., C.W.S.), and Preclinical Pharmacology Section (E.B.T., C.W.S.), Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland chloe.jordan@nih.gov.
Bree A HumburgMolecular Targets and Medications Discovery Branch (C.J.J., B.A.H., A.B.S., Z.-X.X., A.H.N.), Designer Drug Research Unit (M.H.B., C.W.S.), and Preclinical Pharmacology Section (E.B.T., C.W.S.), Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland.
Eric B ThorndikeMolecular Targets and Medications Discovery Branch (C.J.J., B.A.H., A.B.S., Z.-X.X., A.H.N.), Designer Drug Research Unit (M.H.B., C.W.S.), and Preclinical Pharmacology Section (E.B.T., C.W.S.), Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland.
Anver Basha ShaikMolecular Targets and Medications Discovery Branch (C.J.J., B.A.H., A.B.S., Z.-X.X., A.H.N.), Designer Drug Research Unit (M.H.B., C.W.S.), and Preclinical Pharmacology Section (E.B.T., C.W.S.), Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland.
Zheng-Xiong XiMolecular Targets and Medications Discovery Branch (C.J.J., B.A.H., A.B.S., Z.-X.X., A.H.N.), Designer Drug Research Unit (M.H.B., C.W.S.), and Preclinical Pharmacology Section (E.B.T., C.W.S.), Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland.
Michael H BaumannMolecular Targets and Medications Discovery Branch (C.J.J., B.A.H., A.B.S., Z.-X.X., A.H.N.), Designer Drug Research Unit (M.H.B., C.W.S.), and Preclinical Pharmacology Section (E.B.T., C.W.S.), Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland.
Amy Hauck NewmanMolecular Targets and Medications Discovery Branch (C.J.J., B.A.H., A.B.S., Z.-X.X., A.H.N.), Designer Drug Research Unit (M.H.B., C.W.S.), and Preclinical Pharmacology Section (E.B.T., C.W.S.), Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland.
Charles W SchindlerMolecular Targets and Medications Discovery Branch (C.J.J., B.A.H., A.B.S., Z.-X.X., A.H.N.), Designer Drug Research Unit (M.H.B., C.W.S.), and Preclinical Pharmacology Section (E.B.T., C.W.S.), Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland CSCHIND@intra.nida.nih.gov.
National Institute on Drug Abuse · US

Funding

NOVEL DOPAMINE D3 RECEPTOR LIGANDSZ01DA000424 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI NEWMAN, AMY HAUCK · 1999 to 2008
$1.8M
Development of Dual Dopamine/Serotonin Releasing AgentsZ01DA000522 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI ROTHMAN, RICHARD · 2008 to 2008
$598k
Intramural NIH HHS Z01 DA000424Intramural NIH HHS Z01 DA000522
6 · The paper itself

Abstract

Opioid and cocaine abuse are major public health burdens. Existing medications for opioid use disorder are limited by abuse liability and side effects, whereas no treatments are currently approved in the United States for cocaine use disorder. Dopamine D

Indexed as

AnimalsBlood PressureCocaineDopamine AntagonistsDose-Response Relationship, DrugHeart RateIndolesMaleNitrilesOxycodonePiperazinesPiperidinesRatsRats, Long-EvansReceptors, Dopamine D3Tetrahydroisoquinolines3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indoleCocaineDopamine AntagonistsIndolesNitrilesOxycodonePiperazinesPiperidinesReceptors, Dopamine D3R-VK4-40SB 277011TetrahydroisoquinolinesVK4-116

Identifiers

PMID31562201
PMCPMC6863462
OpenAlexW2975386822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.