Evidence map›Paper›PMID 31562185›Full record

ArticleThe Journal of general physiology2019

Voltage-clamp recordings of light responses from wild-type and mutant mouse cone photoreceptors.

Norianne T Ingram, Alapakkam P Sampath, Gordon L Fain

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of general physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 55 citations in OpenAlex.

  1. E122Q rhodopsin: pigment microspectrophotometry, photoreceptor light responses, and bleaching adaptation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Article
  2. Article
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  4. Zoological research · 2026
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  5. Article
  6. The Role of the CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  10. A non-conducting role of the CabioRxiv : the preprint server for biology · 2024
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  11. Review
  12. Article
  13. Article
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  15. Article
  16. Light Adaptation of Retinal Rod Bipolar Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  17. Article
  18. Biomedical optics express · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Norianne T IngramDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA.
Alapakkam P SampathDepartment of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA.ORCID 0000-0002-0785-9577
Gordon L FainDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA gfain@ucla.edu.ORCID 0000-0002-9813-0342
University of California, Los Angeles · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xian-Jie Yang · 1985 to 2026
$16.8M
PHYSIOLOGY OF PHOTORECEPTORSR01EY001844 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GORDON Lee FAIN · 1985 to 2026
$9.9M
PHYSIOLOGY OF PHOTORECEPTORSR37EY001844 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FAIN, GORDON LEE · 1990 to 1999
–
NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY001844NEI NIH HHS R37 EY001844
6 · The paper itself

Abstract

We describe the first extensive study of voltage-clamp current responses of cone photoreceptors in unlabeled, dark-adapted mouse retina using only the position and appearance of cone somata as a guide. Identification was confirmed from morphology after dye filling. Photocurrents recorded from wild-type mouse cones were biphasic with a fast cone component and a slower rod component. The rod component could be eliminated with dim background light and was not present in mouse lines lacking the rod transducin-α subunit (

Indexed as

AnimalsCalcium-Binding ProteinsCalcium SignalingConnexinsGap Junction delta-2 ProteinMiceMice, KnockoutMutationPatch-Clamp TechniquesRetinal Cone Photoreceptor CellsTransducinCalcium-Binding ProteinsConnexinsGap Junction delta-2 ProteinGnat1 protein, mouseTransducin

Identifiers

PMID31562185
PMCPMC6829558
OpenAlexW2976053079

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.