Evidence map›Paper›PMID 31562178›Full record

ArticleeNeuro

Elizabeth C Ballinger, Christian P Schaaf, Akash J Patel, Antonia de Maio, Huifang Tao, David A Talmage, Huda Y Zoghbi, Lorna W Role

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

  1. Mecp2 deficiency induces dysphagia in a preclinical model of Rett syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Toward an NGF-based therapy for Rett syndrome.Frontiers in neuroscience · 2026
    Review
  3. Article
  4. Review
  5. Rett syndrome.Nature reviews. Disease primers · 2024
    Review
  6. Article
  7. Article
  8. NeuRegenerate: A Framework for Visualizing Neurodegeneration.IEEE transactions on visualization and computer graphics · 2023
    Article
  9. Optimized Administration of the MACS chemical neuroscience · 2022
    Article
  10. Clinical and Preclinical Evidence for MNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Elizabeth C BallingerDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794 Elizabeth.Ballinger@StonyBrookMedicine.edu Schaaf@bcm.edu.
Christian P SchaafJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030 Elizabeth.Ballinger@StonyBrookMedicine.edu Schaaf@bcm.edu.
Akash J PatelJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030.
Antonia de MaioProgram in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030.
Huifang TaoJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030.
David A TalmageDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794.ORCID 0000-0003-4627-3007
Huda Y ZoghbiProgram in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030.ORCID 0000-0002-0700-3349
Lorna W RoleDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794.ORCID 0000-0001-5851-212X
Baylor College of Medicine · USStony Brook University · USHoward Hughes Medical Institute · USStony Brook School · US

Funding

MODULATORY EFFECTS OF SUBSTANCE P ON AUTONOMIC NEURONSR01NS022061 · NINDS · STATE UNIVERSITY NEW YORK STONY BROOK · PI PLOTKIN, JOSHUA L · 1985 to 2019
$9.6M
MOLECULAR PATHOGENESIS STUDIES OF RETT SYNDROMER01NS057819 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ZOGHBI, HUDA Y · 2006 to 2025
$7.5M
Phenotypic Effects of MeCP2 Deletion in Cholinergic NeuronsF30MH105087 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI BALLINGER, ELIZABETH C · 2014 to 2016
$65k
NIMH NIH HHS F30 MH105087NINDS NIH HHS R01 NS022061NINDS NIH HHS R01 NS057819
6 · The paper itself

Abstract

Rett Syndrome is a neurological disorder caused by mutations in the gene encoding methyl CpG binding protein 2 (MeCP2) and characterized by severe intellectual disability. The cholinergic system is a critical modulator of cognitive ability and is affected in patients with Rett Syndrome. To better understand the importance of MeCP2 function in cholinergic neurons, we studied the effect of selective

Indexed as

Action PotentialsAnimalsCholinergic NeuronsCholinesterase InhibitorsDisease Models, AnimalDonepezilMethyl-CpG-Binding Protein 2MiceMice, KnockoutOptogeneticsPerirhinal CortexPhenotypeRecognition, PsychologyRett SyndromeCholinesterase InhibitorsDonepezilMethyl-CpG-Binding Protein 2acetylcholineMecp2perirhinalrecognitionRett Syndrome

Identifiers

PMID31562178
PMCPMC6825959
OpenAlexW2976662322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.