ArticleThe Journal of experimental medicine1985
Sera from patients with poststreptococcal glomerulonephritis contain antibodies to glomerular heparan sulfate proteoglycan.
Article in The Journal of experimental medicine, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 70 citations in OpenAlex.
- Mechanisms that potentially contribute to the development of post-streptococcal glomerulonephritis.Pathogens and disease · 2024Review
- Human anti-fibronectin antibodies in systemic lupus erythematosus: occurrence and antigenic specificity.Clinical and experimental immunology · 1994Article
- Evidence for direct anti-heparin-sulphate reactivity in sera of SLE patients.Rheumatology international · 1994Article
- Isolation and characterization of a Streptococcus pyogenes protein that binds to basal laminae of human cardiac muscle.Infection and immunity · 1993Article
- Molecular characterization of a locus required for hyaluronic acid capsule production in group A streptococci.The Journal of experimental medicine · 1992Article
- Autoimmunity and glomerulonephritis.Postgraduate medical journal · 1992Review
- A human monoclonal IgM with autoantibody activities against heparan sulphate and the mitotic spindle.Clinical and experimental immunology · 1990Article
- Immunogenicity of liposome-bound hyaluronate in mice. At least two different antigenic sites on hyaluronate are identified by mouse monoclonal antibodies.The Journal of experimental medicine · 1988Article
- Renal autoimmune epitope of group A streptococci specified by M protein tetrapeptide Ile-Arg-Leu-Arg.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Reaction of bacterium-primed murine T cells to cartilage components: a clue for the pathogenesis of arthritis?Clinical and experimental immunology · 1988Article
- Antibodies to basement membrane proteins nidogen and laminin in sera from streptococcal-related diseases and juvenile rheumatoid arthritis patients.Clinical and experimental immunology · 1987Article
- Antigens of the human glomerular basement membrane.Springer seminars in immunopathology · 1987Review
- Induction of antibodies to hyaluronic acid by immunization of rabbits with encapsulated streptococci.The Journal of experimental medicine · 1986Article
- Antibodies to basement membrane heparan sulfate proteoglycans bind to the laminae rarae of the glomerular basement membrane (GBM) and induce subepithelial GBM thickening.The Journal of experimental medicine · 1986Article
- Antibodies to basement membrane collagen and to laminin are present in sera from patients with poststreptococcal glomerulonephritis.The Journal of experimental medicine · 1986Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibodies, found in human sera from patients with poststreptococcal glomerulonephritis, against proteoglycans (PG) derived from bovine and human glomeruli were investigated. PG were isolated by 4 M guanidine-HCl extraction of whole glomeruli, followed by DEAE-Sepharose CL-6B ion exchange chromatography. The anionic fractions were further purified by chromatography on Sepharose CL-4B. Biochemical analysis of the two resulting peaks revealed the presence of high molecular weight anionic material containing protein, uronic acid, glucosamine, and galactosamine. Enzymatic and chemical susceptibilities indicated the presence of heparan sulfate PG and a galactosamine-containing PG. Immunologic studies revealed the presence of anti-PG antibodies to both PG peaks of the Sepharose CL-4B column in glomerulonephritis sera. Inhibition studies using an ELISA demonstrated that heparan sulfate was a major antigenic determinant. Cross-reactivity with both mammalian and streptococcal hyaluronate was noted. Inhibition studies also indicated the presence of a second antigenic site containing N-acetylgalactosamine, possibly representing chondroitin or dermatan sulfate PG.
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