ArticleMutation research. Genetic toxicology and environmental mutagenesis2019
Mycoplasma infection of cultured cells induces oxidative stress and attenuates cellular base excision repair activity.
Article in Mutation research. Genetic toxicology and environmental mutagenesis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Current Perspectives on 2D and 3D Cell Culture Models in Cancer Research: Molecular Determinants of Tumor Biology and Therapeutic Response.Current issues in molecular biology · 2026Review
- Enhanced antioxidant and anti-Mycoplasma hyopneumoniae activities of combined Piper sarmentosum and guava leaf extracts.The Journal of veterinary medical science · 2025Article
- Modulating oxidative stress: a reliable strategy for coping with community-acquired pneumonia in older adults.Frontiers in medicine · 2025Review
- Cultivated meat microbiological safety considerations and practices.Comprehensive reviews in food science and food safety · 2025Review
- Minimal Bacterial Cell JCVI-syn3B as a Chassis to Investigate Interactions between Bacteria and Mammalian Cells.ACS synthetic biology · 2024Article
- Article
- Measuring DNA modifications with the comet assay: a compendium of protocols.Nature protocols · 2023Review
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- Immune and Oxidative Response against Sonicated Antigen ofMicroorganisms · 2022Article
- Intratumor microbiome in cancer progression: current developments, challenges and future trends.Biomarker research · 2022Review
- A High-Throughput Comet Assay Approach for Assessing Cellular DNA Damage.Journal of visualized experiments : JoVE · 2022Article
- Methylsulfonylmethane ameliorates inflammation via NF-κB and ERK/JNK-MAPK signaling pathway in chicken trachea and HD11 cells during Mycoplasma gallisepticum infection.Poultry science · 2022Article
- Mycoplasmas as Host Pantropic and Specific Pathogens: Clinical Implications, Gene Transfer, Virulence Factors, and Future Perspectives.Frontiers in cellular and infection microbiology · 2022Review
- Report of a clinical and laboratory management of cell therapy for knee cartilage in the face of mycoplasma contamination.Einstein (Sao Paulo, Brazil) · 2022Article
- The Relationship betweenJournal of oncology · 2021Review
- Mycoplasmas-Host Interaction: Mechanisms of Inflammation and Association with Cellular Transformation.Microorganisms · 2020Review
- Genome-Wide Adductomics Analysis Reveals Heterogeneity in the Induction and Loss of Cyclobutane Thymine Dimers across Both the Nuclear and Mitochondrial Genomes.International journal of molecular sciences · 2019Article
- Link Prediction in Multipartite Graphs With Application to Drug Repositioning Studies.IEEE transactions on computational biology and bioinformaticsArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mycoplasma contamination is a major concern for in vitro cell culture models as its resistance to most antibiotics, which makes the prevention and treatment of infection challenging. Furthermore, numerous studies show that Mycoplasma infection alters a variety of cellular processes, in a wide range of cell lines. However, there is a lack of information pertaining to the effects of Mycoplasma infection on genomic stability. In this study, a dopaminergic neuronal cell line (BE-M17), a popular in vitro model for Parkinson's disease, was used to evaluate the effect of Mycoplasma infection on genomic instability, and base excision repair (BER) activity, using single cell gel electrophoresis (the comet assay). The results showed that Mycoplasma infection induced oxidative stress in the absence of an inflammatory response, with markedly increased levels of DNA damage [strand breaks/alkali-labile sites (SB/ALS), and oxidised purines], compared to uninfected cells. The source of the oxidative stress may have been increased ROS generation, or attenuation of cellular antioxidant capacity (or a combination of both). Uninfected cells initially repaired SB/ALS more rapidly than infected cells, although SB/ALS were fully repaired in both uninfected and infected cells 2 h after H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.