ArticleMaturitas2019
Older women are frailer, but less often die then men: a prospective study of older hospitalized people.
Article in Maturitas, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Trajectory of frailty among the older people in a community setting: A cohort study from the Shizuoka Kokuho Database.Aging clinical and experimental research · 2026Article
- Sex based disparities in glycemic control and hospitalization outcomes of medical patients with diabetes mellitus-a historical cohort study.Internal and emergency medicine · 2026Article
- Health conditions of older adults in complex humanitarian settings in low- and middle-income countries: a retrospective analysis of 2019-2025 data from Médecins Sans Frontières-supported inpatient departments.BMJ global health · 2025Article
- Frailty Trajectories and Social Determinants of Health of Older Adults in Rural and Urban Areas in the U.S.Journal of ageing and longevity · 2025Article
- Low relative sit-to-stand power is associated with history of falls and fractures, prospective hospitalization, and all-cause mortality in older adults from the Toledo study for healthy aging.Journal of sport and health science · 2025Article
- Reasons for hospitalisation and cumulative mortality in people, 75 years or older, at high risk of hospital admission: a prospective study.BMC geriatrics · 2024Observational
- Gender differences in the incidence, characteristics and hospital admission outcomes of fall-related injuries in older adults in Victoria, Australia, over 5 years from 2018/19 to 2022/23.Frontiers in public health · 2024Article
- Comprehensive, continuous, and compulsory monitoring of frailty in elderly.Journal of family medicine and primary care · 2023Article
- Association of Vulnerability Screening on Hospital Admission with Discharge to Rehabilitation-Oriented Care after Acute Hospital Stay.Annals of geriatric medicine and research · 2023Article
- Medium and long-term prognosis in hospitalised older adults with multimorbidity. A prospective cohort study.PloS one · 2023Article
- Prognostic Signature of Chronic Kidney Disease in Advanced Age: Secondary Analysis from the InGAH Study with One-Year Follow-Up.Biomolecules · 2022Article
- Sex Difference in the Case Fatality of Older Myocardial Infarction Patients.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Multidimensional prognostic index (MPI) predicts successful application for disability social benefits in older people.Aging clinical and experimental research · 2021Article
- Clinical Frailty Scale and Biomarkers for Assessing Frailty in Elder Inpatients in China.The journal of nutrition, health & aging · 2021Article
- Social inequalities in heat-attributable mortality in the city of Turin, northwest of Italy: a time series analysis from 1982 to 2018.Environmental health : a global access science source · 2020Article
- Using the Multidimensional Prognostic Index (MPI) to improve cost-effectiveness of interventions in multimorbid frail older persons: results and final recommendations from the MPI_AGE European Project.Aging clinical and experimental research · 2020Review
- Validation and Adaptation of the Multidimensional Prognostic Index in an Older Australian Cohort.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
15 authors at 11 institutions in 8 countries.
Funding
Abstract
objectivesThe association between frailty, mortality and sex is complex, but a limited literature is available on this topic, particularly for older hospitalized patients. Therefore, the objective of our study was to prospectively evaluate sex differences in frailty, assessed by the Multidimensional Prognostic Index (MPI) and mortality, institutionalization, and re-hospitalization in an international cohort of older people admitted to hospital. STUDY
designWe used data from nine public hospitals in Europe and Australia, to evaluate sex differences in mortality, frailty and the risk of institutionalization and re-hospitalization, during one year of follow-up.
main outcome measuresPeople aged 65 years or more admitted to hospital for an acute medical condition or for a relapse of a chronic disease were included. A standardized comprehensive geriatric assessment, which evaluated functional, nutritional, and cognitive status, risk of pressure sores, comorbidities, medications and co-habitation status, was used to calculate the MPI to measure frailty in all hospitalized older people. Data regarding mortality, institutionalization and re-hospitalization were also recorded for one year.
resultsAltogether, 1140 hospitalized patients (mean age = 84.2 years; 694 women = 60.9%) were included. The one-year mortality rate was 33.2%. In multivariate analysis, adjusted for age, MPI score, centre and diagnosis at baseline, although women had higher MPI scores than men, the latter had higher in-hospital (odds ratio, OR = 2.26; 95% confidence intervals, CI = 1.27-4.01) and one-year post-discharge mortality (OR = 2.04; 95%CI = 1.50-2.79). Furthermore, men were less frequently institutionalized in a care home than female patients (OR = 0.55; 95%CI: 0.34-0.91), but they were also more frequently re-hospitalized (OR = 1.42; 95%CI: 1.06-1.91) during the year after hospital discharge.
conclusionOlder hospitalized men were less frail, but experienced higher in-hospital and one-year mortality than women. Women were admitted more frequently to nursing homes and experienced a lower risk of re-hospitalization. These findings suggest important differences between the sexes and extends the 'male-female health-survival paradox' to acutely ill patient groups.
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