Evidence map›Paper›PMID 31561738›Full record

ReviewAnnual review of pharmacology and toxicology2020

β

Kwun Nok Mimi Man, Manuel F Navedo, Mary C Horne, Johannes W Hell

Abstract readReview
In one paragraph

Review in Annual review of pharmacology and toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Signalling of Adrenoceptors: Canonical Pathways and New Paradigms.Handbook of experimental pharmacology · 2024
    Review
  6. Regulation of the CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  7. αeLife · 2023
    Article
  8. Mechanisms of Vascular CaHandbook of experimental pharmacology · 2023
    Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kwun Nok Mimi ManDepartment of Pharmacology, University of California, Davis, California 95616, USA; email: jwhell@ucdavis.edu.
Manuel F NavedoDepartment of Pharmacology, University of California, Davis, California 95616, USA; email: jwhell@ucdavis.edu.
Mary C HorneDepartment of Pharmacology, University of California, Davis, California 95616, USA; email: jwhell@ucdavis.edu.
Johannes W HellDepartment of Pharmacology, University of California, Davis, California 95616, USA; email: jwhell@ucdavis.edu.

Funding

Coupling of Vascular Cav1.2 Channels In Health & DiseaseR01HL121059 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2015 to 2024
$4.5M
Role of a-actinin in Cav1.2 FunctionR01AG055357 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOHANNES W HELL · 2016 to 2026
$4.0M
Calcium Sparklets-Induced Vascular Dysfunction During DiabetesR01HL098200 · NHLBI · UNIVERSITY OF WASHINGTON · PI NAVEDO, MANUEL F · 2010 to 2019
$3.5M
Molecular Mechanisms of Postsynaptic AMPA Receptor LocalizationR01MH097887 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2014 to 2018
$2.5M
Signaling by cAMP within postsynaptic nano domains R01NS078792R01NS078792 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2016
$2.0M
NHLBI NIH HHS R01 HL098200NHLBI NIH HHS R01 HL121059NIA NIH HHS R01 AG055357NIMH NIH HHS R01 MH097887NINDS NIH HHS R01 NS078792
6 · The paper itself

Abstract

Formation of signaling complexes is crucial for the orchestration of fast, efficient, and specific signal transduction. Pharmacological disruption of defined signaling complexes has the potential for specific intervention in selected regulatory pathways without affecting organism-wide disruption of parallel pathways. Signaling by epinephrine and norepinephrine through α and β adrenergic receptors acts on many signaling pathways in many cell types. Here, we initially provide an overview of the signaling complexes formed between the paradigmatic β

Indexed as

AnimalsCalcium Channels, L-TypeCyclic AMP-Dependent Protein KinasesEpinephrineHumansNorepinephrineReceptors, Adrenergic, beta-2Receptors, AMPASignal TransductionCACNA1C protein, humanCalcium Channels, L-TypeCyclic AMP-Dependent Protein KinasesEpinephrineNorepinephrineReceptors, Adrenergic, beta-2Receptors, AMPAadenylyl cyclaseAKAPcAMPGsnorepinephrinePSD-95

Identifiers

PMID31561738
PMCPMC7029424

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.